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Self-assembly and bioactive response of a crystalline metal oxide in a simulated blood fluid

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Abstract

In this study we report on the bioactive response of self-assembled niobium oxide microstructures when immersed in a supersaturated solution emulating mineral content in blood. The structures were formed via electrochemical anodization in an electrolyte comprised of HF and NaF. The slow oxide formation kinetics associated with the presence of NaF in the electrolyte enabled microscopic examinations during microstructure evolution as shown via scanning electron microscopy (SEM). Apparently the slow growth kinetics encourage the development of bioactive sites on the microstructures, as these structures induced mineral formations. On the other hand, microstructures grown in the absence of salt were ineffective mineral nucleators. Analysis of nucleated mineral deposits was performed using X-ray diffraction and Raman spectroscopy. Both long-range and short-range order experiments verified the nucleated mineral phase was hydroxyapatite (HAP). Further characterization of the mineral phase was observed using SEM and revealed effective nucleation sites were predominantly isolated to loci on the ordered microbodies as opposed to locations lying within the amorphous strata.

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Acknowledgments

Support for this study was funded by the Oral Health Research Institute. The authors thank Ms. Y.H. Cho at National Center for Inter-University Research Facilities at Seoul National University for assistance and use of the Raman spectrometer. The authors also thank Dr. Jeffrey Swope and Mr. Vince Hernly at IUPUI for assistance with X-ray diffraction. The authors are grateful to A.T. Hara for valuable discussions and give special thanks to Clif W. Duhn for assistance with image processing.

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Authors and Affiliations

  1. Department of Preventive & Community Dentistry, Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis, IN, 46202, USA

    Robert Lynn Karlinsey

  2. School of Earth and Environmental Sciences, Seoul National University, Seoul, 151-747, Korea

    Keewook Yi

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  1. Robert Lynn Karlinsey
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  2. Keewook Yi
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Correspondence to Robert Lynn Karlinsey.

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Karlinsey, R.L., Yi, K. Self-assembly and bioactive response of a crystalline metal oxide in a simulated blood fluid. J Mater Sci: Mater Med 19, 1349–1354 (2008). https://doi.org/10.1007/s10856-007-3164-9

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  • DOI: https://doi.org/10.1007/s10856-007-3164-9

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