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The behaviour of selected yttrium containing bioactive glass microspheres in simulated body environments

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Abstract

The study aims at the manufacture and investigation of biodegradable glass microspheres incorporated with yttrium potentially useful for radionuclide therapy of cancer. The glass microspheres in the SiO2–Na2O–P2O5–CaO–K2O–MgO system containing yttrium were prepared by conventional melting and flame spheroidization. The behaviour of the yttrium silicate glass microspheres was investigated under in vitro conditions using simulated body fluid (SBF) and Tris buffer solution (TBS), for different periods of time, according to half-life time of the Y-90. The local structure of the glasses and the effect of yttrium on the biodegradability process were evaluated by Fourier Transform Infrared (FT-IR) spectroscopy and Back Scattered Electron Imaging of Scanning Electron Microscopy (BEI-SEM) equipped with Energy Dispersive X-ray (EDX) analysis. UV–VIS spectrometry and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) was used for analyzing the release behaviour of silica and yttrium in the two used solutions. The results indicate that the addition of yttrium to a bioactive glass increases its structural stability which therefore, induced a different behaviour of the glasses in simulated body environments.

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Acknowledgements

Marie Curie Fellowships Program (HPMT-CT-2001-00297) at Åbo Akademi University, Process Chemistry Centre and CNCSIS program (Grant TD 2/32) at Babes-Bolyai University, Faculty of Physics, are acknowledged for the financial support of this work.

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Authors and Affiliations

  1. Faculty of Physics, Babes-Bolyai University, M. Kogalniceanu 1, Cluj-Napoca, 400084, Romania

    D. Cacaina & S. Simon

  2. Turku Biomaterials Centre, University of Turku, Itäinen Pitkäkatu 4 B (PharmaCity), Turku, 20500, Finland

    D. Cacaina & H. Ylänen

  3. Process Chemistry Centre, Åbo Akademi University, Biskopsgatan 8, Turku, 20500, Finland

    M. Hupa

Authors
  1. D. Cacaina
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  2. H. Ylänen
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  3. S. Simon
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  4. M. Hupa
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Correspondence to D. Cacaina.

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Cacaina, D., Ylänen, H., Simon, S. et al. The behaviour of selected yttrium containing bioactive glass microspheres in simulated body environments. J Mater Sci: Mater Med 19, 1225–1233 (2008). https://doi.org/10.1007/s10856-007-3163-x

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  • DOI: https://doi.org/10.1007/s10856-007-3163-x

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