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Synthesis of carbonated hydroxyapatite nanospheres through nanoemulsion

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Abstract

This study investigated the nanoemulsion technique as a means to synthesize carbonated hydroxyapatite (CHAp) nanospheres which could be used to produce composite tissue engineering scaffolds. CHAp nanospheres were successfully synthesized by mixing an acetone solution of Ca(NO3)2 · 4H2O with an aqueous solution of (NH4)2HPO4 and NH4HCO3. Four reaction temperatures, namely, 4, 25, 37 and 55 °C, were investigated and no surfactant was added in all nanoemulsion processes. Wet slurries of CHAp from the nanoemulsions were freeze-dried to obtain dry powders. X-ray diffraction (XRD) results showed that the as-synthesized CHAp nanoparticles were mainly in an amorphous state. After calcination at 900 °C, the apatite became well crystallized. Fourier transform infrared (FTIR) spectroscopy showed that the CHAp was B-type substitution. Both scanning electron microscopy (SEM) and transmission electron microscopy (TEM) revealed that the CHAp particles were spherical in shape and that their sizes were in the nanometer range. The successful synthesis of CHAp nanospheres is a critical step forward in our efforts to fabricate bone tissue engineering scaffolds using the selective laser sintering technology.

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Acknowledgments

This work was supported by a CERG research grant (HKU 7118/05E) from the Hong Kong Research Grants Council. W. Y. Zhou thanks The University of Hong Kong for providing him with a research studentship.

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Authors and Affiliations

  1. Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, Hong Kong, China

    W. Y. Zhou, M. Wang & W. L. Cheung

  2. Department of Polymer Materials and Engineering, South China University of Technology, Guangzhou, 510640, China

    B. C. Guo & D. M. Jia

Authors
  1. W. Y. Zhou
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  2. M. Wang
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  3. W. L. Cheung
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  4. B. C. Guo
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  5. D. M. Jia
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Correspondence to W. L. Cheung.

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Zhou, W.Y., Wang, M., Cheung, W.L. et al. Synthesis of carbonated hydroxyapatite nanospheres through nanoemulsion. J Mater Sci: Mater Med 19, 103–110 (2008). https://doi.org/10.1007/s10856-007-3156-9

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  • DOI: https://doi.org/10.1007/s10856-007-3156-9

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