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Fixation of experimental osteotomies with bioabsorbable SR-polylactide–polyglycolide (80/20) polymeric rods

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Abstract

Self-reinforced polylactide–polyglycolide (80/20) composite rods, 2 mm in diameter and 36 mm in length, were implanted into the dorsal subcutaneous tissue of 20 rabbits. Osteotomies of the distal femur were fixed with these rods (2 × 15 mm) in the rabbits. The follow-up times varied from 3 to 104 weeks. After sacrifice, three-point bending and shear tests and molecular weight measurements were performed for subcutaneously placed rods. Radiological, histological, microradiographic, oxytetracycline-fluorescence, and histomorphometrical studies of the osteotomized and intact control femora were performed. After 6 weeks the mechanical properties had decreased significantly, but osteotomies had healed uneventfully. The present investigation showed that the mechanical strength and fixation properties of SR-Polylactide–glycolide (80/20) rods are suitable for fixation of cancellous bone osteotomies in rabbits provided that the operative technique is correct. The present article is the first report on the application of these rods for fixation of cancellous bone osteotomies.

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Acknowledgements

The authors thank Ms. Ritva Sohlman and Mrs. Johanna Virri for their technical assistance. This study was supported by grants from the Foundation for Orthopaedical and Traumatological Research in Finland, the National Technology Agency, the Academy of Finland, and the Medical Foundation of Finland.

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Authors and Affiliations

  1. Department of Orthopaedics and Traumatology, University of Helsinki and Helsinki University Central Hospital, P.O. Box 266, Helsinki, 00029 HUS, Finland

    Eeva Mäkelä, E. Antero Mäkelä, Esa K. Partio, Timo Juutilainen & Pentti Rokkanen

  2. Linvatec Biomaterials Oy Ltd, Hermiankatu 6-8 L, P.O. Box 3, Tampere, 33721, Finland

    Kimmo Lähteenkorva

  3. Institute of Biomaterials, Tampere University of Technology, P.O. Box 589, Tampere, 33101, Finland

    Pertti Törmälä

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  1. Eeva Mäkelä
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  2. E. Antero Mäkelä
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  3. Esa K. Partio
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  4. Timo Juutilainen
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  6. Pertti Törmälä
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  7. Pentti Rokkanen
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Correspondence to Timo Juutilainen.

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Mäkelä, E., Mäkelä, E.A., Partio, E.K. et al. Fixation of experimental osteotomies with bioabsorbable SR-polylactide–polyglycolide (80/20) polymeric rods. J Mater Sci: Mater Med 19, 1061–1067 (2008). https://doi.org/10.1007/s10856-007-3150-2

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  • DOI: https://doi.org/10.1007/s10856-007-3150-2

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