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Degradable phosphate glass fiber reinforced polymer matrices: mechanical properties and cell response

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Abstract

The development of biodegradable materials for internal fracture fixation is of great interest, as they would both eliminate the problem of stress shielding and obviate the need for a second operation to remove fixation devices. Preliminary investigations for the production of degradable fiber reinforced polymer composite materials are detailed. Composites were produced of phosphate invert glass fibers of the glass system P2O5–CaO–MgO–Na2O–TiO2, which showed a low solubility in previous work. The fibers were embedded into a matrix of a degradable organic polymer network based on methacrylate-modified oligolactide. Fracture behavior, bending strength and elastic modulus were evaluated during 3-point bending tests and the fracture surface of the composites was investigated using a scanning electron microscope. Short-term biocompatibility was tested in an FDA/EtBr viability assay using MC3T3-E1 murine pre-osteoblast cells and showed a good cell compatibility of the composite materials. Results suggested that these composite materials are biocompatible and show mechanical properties which are of interest for the production of degradable bone fixation devices.

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Acknowledgments

The authors would like to thank Dr. Jens Kobelke of the Institute for Physical High Technology (IPHT) Jena for his support with fiber production.

Financial support of this work by the Ministry of Science, Research and Art of Thuringia, Germany (grant B 478-02001) is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Materials, Imperial College London, Exhibition Road, London, SW7 2AZ, UK

    Delia S. Brauer

  2. Otto-Schott-Institut, Friedrich-Schiller-Universität Jena, Fraunhoferstr. 6, 07743, Jena, Germany

    Christian Rüssel

  3. Biomaterials Department, Innovent e.V, Prüssingstr. 27B, 07745, Jena, Germany

    Sebastian Vogt, Jürgen Weisser & Matthias Schnabelrauch

Authors
  1. Delia S. Brauer
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  2. Christian Rüssel
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  3. Sebastian Vogt
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  4. Jürgen Weisser
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  5. Matthias Schnabelrauch
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Correspondence to Delia S. Brauer.

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Brauer, D.S., Rüssel, C., Vogt, S. et al. Degradable phosphate glass fiber reinforced polymer matrices: mechanical properties and cell response. J Mater Sci: Mater Med 19, 121–127 (2008). https://doi.org/10.1007/s10856-007-3147-x

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  • DOI: https://doi.org/10.1007/s10856-007-3147-x

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