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Sol–gel processing of drug delivery zirconia/polycaprolactone hybrid materials

Journal of Materials Science: Materials in Medicine volume 19, pages 531–540 (2008)Cite this article

Abstract

Poly(є-caprolactone) (PCL 6, 12 and 24 wt%) and zirconium (ZrO2) organic–inorganic hybrid materials have been synthesized by the sol–gel method from a multicomponent solution containing zirconium propoxide [Zr(OC2H7)4], poly(ε-caprolactone) (PCL), water, chloroform (CHCl3). Sodium ampicillin was incorporate in the hybrid materials to verify the effect as local controlled drug delivery system. The structure of interpenetrating network is realized by hydrogen bonds between Zr-OH group (H donator) in the sol–gel intermediate species and carboxylic group (H-acceptor) in the repeating units of the polymer. The presence of hydrogen bonds between organic/inorganic components of the hybrid material was proved by FTIR analysis. The morphology of the hybrid material was studied by scanning electron microscope (SEM). The structure of a molecular level dispersion has been disclosed by atomic force microscope (AFM), pore size distribution and surface measurements. The bioactivity of the synthesized hybrid material has been showed by the formation of a layer of hydroxyapatite on the surface of PCL/ZrO2 samples soaked in a fluid simulating the composition of the human blood plasma. Release kinetics in a simulate body fluid (SBF) have been subsequently investigate. The amount of sodium ampicillin released has been detected by UV–VIS spectroscopy and SEM. The release kinetics seems to occur in more than one stage. HPLC analysis has also been taken to ensure the integrity of ampicillin after the synthetic treatment.

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References

  1. C. SANCHEZ and F. RIBOT, in Proceedings of the First European Workshop on Hybrid organic–inorganic Materials (Synthesis, Properties, Applications), Bierville-France, (1993).

  2. Hybrid Organic–inorganic Materials edited by L.L KLEIN and C. SANCHEZ Special Issue of J. Sol–Gel Sci. Tech. 5 (1995)

  3. C. SANCHEZ and F. RIBOT, New. J. Chem. 18 (1994) 1007

    CAS  Google Scholar 

  4. P. JUDEINSTEIN and C. SANCHEZ, J. Mater. Chem. 6 (1996) 511

    Article  CAS  Google Scholar 

  5. L. L HENCH and J. K. WEST, Chem. Rev. 90 (1990) 33

    Article  CAS  Google Scholar 

  6. B. M. NOVAK, Adv. Mater. 5 (1993) 422

    Article  CAS  Google Scholar 

  7. G. H. HSIUE, J. K. KUO, R. J. JENG, J. I. CHEN, X. L. JIANG, S. MARTURUNKAKUL, J. KUMAR and S. K. TRIPATHY, Chem. Mater. 6 (1994) 884

    Article  CAS  Google Scholar 

  8. Y. WEI, J. XU, H. DONG, J. H. DONG, K. Y. QIU and S. A. JANSON-VARNUM, Chem. Mater. 11 (1999) 2023

    Article  CAS  Google Scholar 

  9. C. J. BRINKER and G. W. SCHERER, 1989, in Sol–Gel science, the physics and chemistry of Sol–Gel processing (San Diego: Academic Press)

  10. L. C. KLEIN, 1988, in Sol–Gel technology (Park Ridge NJ: Noyes PublicaZrons)

  11. I. A. DAVID and G. W. SCHERER, Chem. Mater. 7 (1995) 195

    Article  Google Scholar 

  12. J. J. FITZGERALD, C. J. T. LANDRY and J. M. POCHAN, Macromolecules 25 (1992) 3715

    Article  CAS  Google Scholar 

  13. T. SAEGUSA, Macromol. Symp. 98 (1995) 719

    CAS  Google Scholar 

  14. M. CATAURO, M. G. RAUCCI, F. DE GAETANO and A. MAROTTA, J. Mater. Sci. 38 (2003) 3102

    Article  Google Scholar 

  15. M. CATAURO, M. G. RAUCCI, F. DE GAETANO, A. BURI, A. MAROTTA and L. AMBROSIO, J. Mater. Sci. 38 (2004) 991

    Google Scholar 

  16. T. KOKUBO, H. -M. KIM and M. KAWASHITA, Biomaterials 24 (2003) 2161

    Article  CAS  Google Scholar 

  17. T. KOKUBO, 1999, Boll. Soc. Esp. Ceram.Vid.,in Proceedings of the XVI Int. Cong. on Glass, Madrid, 1992, 1(31-C1), 119

  18. C. OHTSUKI, T. KOKUBO and T. YAMAMURO, J. Non - Cyst. Solids 143 (1992) 84

    Article  CAS  Google Scholar 

  19. L. L. HENCH and D. E. CLARK, J. Non-Cryst. Solids 28 (1978) 83

    Article  CAS  Google Scholar 

  20. A. PAUL, 1990, in Chemistry of glasses, 2nd edn (London, New York: Chapman and Hall) p. 184

    Google Scholar 

  21. D. S. BANSAL and C. G. PANTANO, Non-Cryst. Solids 115 (1992) 147

    Google Scholar 

  22. M. THOMAS, 1996, in Ultraviolet and Visible Spectroscopy, 2nd edn, edited by D.J. ANDO (England: Wiley) pp. 16–30.

  23. C. SANCHEZ, J. LIVAGE, M. HENRY and F. BABONNEAU, J. Non-Cryst. Solids 100 (1988) 650

    Article  Google Scholar 

  24. E. RADLEIN and G. H. FRISCHOT, J. Non-Crist. Solids 222 (1997) 69

    CAS  Google Scholar 

  25. Y. WEI, J. DANLIANG, D. BRENNAN, D. N. RIVERA, Q. ZHUANG, N. J. DI NARDO and K. QIU, Chem. Mater. 10 (1998) 769

    Article  CAS  Google Scholar 

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Affiliations

  1. Department of Aerospace and Mechanical Engineering, Second University of Naples, Via Roma n°21, Aversa, CE, 81031, Italy

    Michelina Catauro

  2. Department of Materials and Production Engineering, University of Naples Federico II, Piazzale Tecchio, Naples, 80125, Italy

    Mariagrazia Raucci

  3. INFM-Coherentia Department of Physics Science, University of Naples Federico II, Piazzale Tecchio, Naples, 80125, Italy

    Giovanni Ausanio

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  1. Michelina Catauro
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  2. Mariagrazia Raucci
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  3. Giovanni Ausanio
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Correspondence to Michelina Catauro.

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Catauro, M., Raucci, M. & Ausanio, G. Sol–gel processing of drug delivery zirconia/polycaprolactone hybrid materials. J Mater Sci: Mater Med 19, 531–540 (2008). https://doi.org/10.1007/s10856-007-3065-y

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  • DOI: https://doi.org/10.1007/s10856-007-3065-y

Keywords

  • Atomic Force Microscopy
  • Y2O3
  • Hybrid Material
  • Simulated Body Fluid
  • Polycaprolactone