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Influence of polyelectrolyte on the thermosensitive property of PNIPAAm-based copolymer hydrogels

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Abstract

A new family of poly(NIPAAm-co-2-acrylamido-2-methyl-1-propanesulfonic acid) [P(NIPAAm-co-AMPSA)] hydrogels was synthesized by incorporating negative charged AMPSA to the backbone of the PNIPAAm-based hydrogel. The effect of polyelectrolyte (i.e., PAMPSA) on the thermosensitive property of PNIPAAm hydrogels was investigated. It was found that P(NIPAAm-co-AMPSA) hydrogels exhibited unique honey-comb-like 3D porous structure having rigid cell wall as well as enhanced mechanical property. The incorporation of AMPSA into PNIPAAm backbones also led to a significant increase in swelling capability at room temperature when comparing to pure PNIPAAm hydrogels. In addition, the shrinking rate upon heating was significantly improved if the AMPSA content in P(NIPAAm-co-AMPSA) hydrogels was less than 10 wt%.

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References

  1. K. N. PARK, W. S. W. SHALABY and H. S. PARK, 1975 Biodegradable hydrogels for drug delivery (Technomic Publication AG. Lancaster, PA) pp. 1–9, chapter 1

  2. N. A. PEPPAS and A. G. MIKOS, Preparation methods and structure of hydrogels. Hydrogels in Medicine and Pharmacy, edited by N.A. Peppas, Vol.1. CRC Press, Boca Raton, FL, 1986, 1–27

  3. A. SILBERBERG, Network deformation in Flow. Molecular basis of polymer. Networks, edited by A. Baumgartner and C.E. Picot, Berlin: Spring-Verlag, 1989, 147–151

  4. B. D. RATNER and A. S. HOFFMAN, Synthetic hydrogels for biomedical applications. Hydrogels for Medical and Related Applications, edited by J.D. Andradre, ACS Symposium Series, American Chemical Society, Washington. D.C., 1976, 31, 1–36

  5. G. CHEN and A. S. HOFFMAN, Nature 373 (1995) 49

    Article  CAS  Google Scholar 

  6. A. M. MIKA, R. F. CHILDS, J. M. DICKSON, B. E. MCCARRY and D. R. GAGNON, J. Membr. Sci. 108 (1995) 37

    Article  CAS  Google Scholar 

  7. Y. HIROSE, G. GIANNETTI, J. MARGUARDT and T. TANAKA, J. Phys. Soc. Jpn. 61 (1992) 4085

    Article  CAS  Google Scholar 

  8. J. P. GANG, J. KAWAKAMI, V. G. SERGEYEV and Y. OSADA, Macromolecules 24 (1991) 5246

    Article  Google Scholar 

  9. T. MIYATA, N. ASAMI and T. URAGAMI, Nature 399 (1999) 766

    Article  CAS  Google Scholar 

  10. Y. HIROKAWA and T. TANAKA, J. Chem. Phys. 81 (1984) 6379

    Article  Google Scholar 

  11. H. FEIL, Y. H. BAE, J. FEIJEN and S. W. KIM, Macromolecules 26 (1993) 2496

    Article  CAS  Google Scholar 

  12. H.G. SCHILD, Prog. Polym. Sci. 17 (1992) 163

    Article  CAS  Google Scholar 

  13. Y. H. BAE, T. OKANO and S. W. KIM, J. Polym. Sci. Part B Polym. Phys. 28 (1990) 923

    Article  CAS  Google Scholar 

  14. N. A. PEPPAS and R. LANGER, Science 263 (1994) 1715

    Article  CAS  Google Scholar 

  15. P. S. STAYTON, T. SHIMOBJI, C. LONG, A. CHILKOTI, G. CHEN, J. M. HARRIS and A. S. HOFFMAN, Nature 378 (1995) 472

    Article  CAS  Google Scholar 

  16. J. KOST and R. LANGER, Adv. Drug Deliver. Rev. 6 (2001) 125

    Article  Google Scholar 

  17. T. SHIROYA, N. TAMURA, M. YASUI and K. FUJIMOTO, Colloid Surf. B 4 (1995) 267

    Article  CAS  Google Scholar 

  18. I. Y. GALAVE, M. N. GUPTA and B. MATTIASSON, Chemtech. 26 (1996) 19

    Google Scholar 

  19. H. FEIL, Y. H. BAE, J. FEIGEN and S. W. KIM, J. Membr. Sci. 64 (1991) 283

    Article  CAS  Google Scholar 

  20. F. ROSSO, A. BARBARISI, M. BARBARISI, O. PETILLO, S. MARGARUCCI, A. CALARCO and G. PELUSO, Mater. Sci. Engi. C 23 (2003) 371

    Article  Google Scholar 

  21. J. K. ANDRADE, S. NAGAOKA, S. COOPER, T. OKANO and S. W. KIM, Trans. – Am. Soc. Artif. Intern. Organs 83 (1987) 75

    Google Scholar 

  22. B. D. RATNER, A. B. JOHNSTON and T. J. LENK, J. Biomed. Mater. Res. Appl. Biomater. 21 (1987) 59

    Article  CAS  Google Scholar 

  23. S. W. Kim and J. Feijens, CRC Critical Reviews in Biocompatibility, edited by D. Williams, Vol. 1(3). CRC Press, Boca Raton, FL. 1985, 229–241

  24. Y. OSADA, H. OKUZAKI and H. HORI, Nature 355 (1992) 242

    Article  CAS  Google Scholar 

  25. H. OKUZAKI and Y. OSADA, Electrochim. Acta. 40 (1995) 2229

    Article  CAS  Google Scholar 

  26. Y. UEOKA, J. P. GONG and Y. OSADA, J. Intelligent Mat. Syst. Str. 8 (1997) 465

    Article  CAS  Google Scholar 

  27. X. Z. ZHANG, D. Q. WU and C. C. CHU, Biomaterials 25 (2004) 3793

    Article  CAS  Google Scholar 

  28. X. Z. ZHANG, D. Q. WU and C. C. CHU, Biomaterials 25 (2004) 4719

    Article  CAS  Google Scholar 

  29. H. TANAKA, H. TOUHARA, K. NAKANISHI, N. WATANABE, J. Chem. Phys. 80 (1984) 5170

    Article  CAS  Google Scholar 

  30. K. OTAKE, H. INOMATA, M. KONNO, S. SAITO, Macromolecules 23 (1990) 283

    Article  CAS  Google Scholar 

  31. S. NAMKUNG, C. C. CHU, J. Biomater. Sci. (In Press)

  32. O. E. PHILIPPOVA, R. RULKENS, B. I. KOVTUNENKO, S. S. ABRAMCHUK, A. R. KHOKHLOV and G. WEGNER, Macromolecules 31 (1998) 1168

    Article  CAS  Google Scholar 

  33. X. S. WU, A. S. HOFFMAN and P. YAGER, J. Polym. Sci., Part A Polym. Chem. 30 (1992) 2121

    Article  CAS  Google Scholar 

  34. X. Z. ZHANG, Y. Y. YANG, T. S. CHUNG and K. X. MA, Langmuir 17 (2001) 6094

    Article  CAS  Google Scholar 

  35. R. X. ZHUO and W. LI, J. Polym. Sci. A Polym. Chem. 41 (2003) 152

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, P.R. China

    Xian-Zheng Zhang

  2. Department of Textiles and Apparel & Biomedical Engineering Program, Cornell University, Ithaca, NY, 14853-4401, USA

    Xian-Zheng Zhang & Chih-Chang Chu

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  1. Xian-Zheng Zhang
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  2. Chih-Chang Chu
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Correspondence to Chih-Chang Chu.

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Zhang, XZ., Chu, CC. Influence of polyelectrolyte on the thermosensitive property of PNIPAAm-based copolymer hydrogels. J Mater Sci: Mater Med 18, 1771–1779 (2007). https://doi.org/10.1007/s10856-007-3040-7

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  • DOI: https://doi.org/10.1007/s10856-007-3040-7

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