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Resistant starch as a carrier for oral colon-targeting drug matrix system

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Abstract

In this study, a novel tablet of protein drug matrix for colon targeting was developed using resistant starch as a carrier prepared by pre-gelatinization and cross-linking of starch. The effects of pre-gelatinization and cross-linking on the swelling and enzymatic degradation of maize starch as well as the release rate of drug from the matrix tablets were examined. Cross-linked pre-gelatinized maize starches were prepared by double modification of pre-gelatinization and cross-linked with POCl3, and bovine serum albumin was used as a model drug. For in vitro drug release assays, the resistant starch matrix tablets were incubated in simulated gastric fluid, simulated intestinal fluid and simulated colonic fluid, respectively. The content of resistant starch and swelling property of maize starch were increased by pre-gelatinization and cross-linking, which retarded its enzymatic degradation. Drug release studies have shown that the matrix tablets of cross-linked pre-gelatinized maize starch could delivery the drug to the colon. These results indicate that the resistant starch carrier prepared by pre-gelatinization and cross-linking can be used for a potential drug delivery carrier for colon-targeting drug matrix delivery system.

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Acknowledgements

This work is supported by the key Fund of National Nature Science of China (20436020), the National Natural Science Fund of China (20606014, 20376027), the Natural Science Fund of Guangdong Province (031350) and the Science and Technology Fund of Guangdong Province (2005A10903002).

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Authors and Affiliations

  1. Institute of Light Industry & Chemical Engineering, South China University of Technology, Guangzhou, 510640, China

    Ling Chen, Xiaoxi Li, Yansheng Pang, Lin Li, Ximei Zhang & Long Yu

  2. Su Zhou Gao Feng Fine Chemicals Co., Ltd., Suzhou, 215128, China

    Yansheng Pang

  3. Commonwealth Scientific and Industrial Research Organization, CMIT, Melbourne, Australia

    Long Yu

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  1. Ling Chen
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  2. Xiaoxi Li
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  3. Yansheng Pang
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  4. Lin Li
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  6. Long Yu
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Correspondence to Xiaoxi Li.

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Chen, L., Li, X., Pang, Y. et al. Resistant starch as a carrier for oral colon-targeting drug matrix system. J Mater Sci: Mater Med 18, 2199–2203 (2007). https://doi.org/10.1007/s10856-007-3009-6

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  • DOI: https://doi.org/10.1007/s10856-007-3009-6

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