Abstract
An artificial cornea consisted of a porous nano-hydroxyapatite/poly (vinyl alcohol) hydrogel (n-HA/PVA-H) skirt and a transparent center poly (vinyl alcohol) hydrogel (PVA-H) were prepared. The n-HA/PVA-H skirt was homogeneously porous and these pores were interconnected. Inter-penetrating network was observed along the interface between the core and the skirt. Artificial corneas were implanted in eyes of rabbit. The corneal tissues were evaluated histological. The results displayed that a good biocompatibility and interlocking had happened between artificial cornea and host tissues. This novel cornea prepared here is potential to be used clinically.
Similar content being viewed by others
References
J.H. LEE, W.R. WEE, E.S. CHUNG ET AL., Arch. Ophthalmol. 118 (2000) 1673.
P.A. NETLAND, H. TERADA and C.H. DOHLMAN, Ophthalmology 105 (1998) 751.
A.D. RUEDEMANN, Trans. Am. Ophthalmol. Soc. 72 (1974) 329.
L.J. GIRARD, R.S. HAWKINS, R.NIEVES and C. GRANT, Am. Acad. Ophthalmol. Otolaryngol. 83 (1977) 252.
G.N. RAO, H.L. BLATT and J.V. AQUAVELLA, Am. J. Ophthalmol. 88 (1979) 190.
TRAIAN V. CHRILA, Biomaterials 22 (2001) 3311.
L.L. HENCH and J. WILSON, Science 226 (1984) 630.
Y. B. LI, X. ZHANG and W. CHEN ET AL., In: Trans 19th Annual Meeting of the Society for Biomaterials. Birmingham, AL, USA, 1993, p.165.
P.DUCHEYNE, J. Biomed. Mater. Res. Appl. Biomater. 21 (1987) 219.
U. HEISE, JF OSBORN and F. DUWE, Int. Orthop. 14 (1990) 329.
C. R LEON, J. J. BARRAQUER and J. S. BARRAQUER, J. Refract. Surg. 13 (1997) 74.
RACHAEL H. SCHMEDLEN and S. KRISTYN, Biomaterials 234 (2002) 325.
G. TSUK A, V. TRINKAS-RABDALL and H.M. LEIBOWIZE, J. Biomed. Mater. Res. 34 (1997) 299.
A. N.PEPPAS, N. K. MONGIA and K. NEENA, Eur. J. Pharm. Biopharm. 43 (1997)51.
S.H. HYON and W.I. CHA, J. Biomater. Sci. Polym. Edn. 5 (1994) 397.
T. H. YOUNG and W. Y. CHUANG, Biomaterials 23 (2002) 3495.
Y.B. LI and K DE GROOT, J Mater Sci.: Mater. Med. 5 (1994) 326.
V. TRINKAUS-RANDALLL, J. CAPECCHI, A. NEWTON and A. VADASZ, Ophthalmol. Vis. Sci. 29 (1988) 393.
C.H. DOHLMAN, and M.G. DOANE, Cornea 13 (1994) 214.
J.M. LEGEAIS, G. RENARD, J.M. PAREL, I. ETS-G and S.A. VOLDELLI M, Arch. Ophthalmol. 113 (1995) 757.
J.H. WHITE and O.GONA, Ophthalmic Surg. 19 (1988) 331.
V. MARCHI, R. RICCI, I. PECORELLA, A. CIARDI and U. DI TONDO, Cornea 13 (1994) 125.
F.L. XU, Y.B. LI and X.J. WANG ET AL., J. Funct. Mater. 35 (2004) 509.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Fenglan, X., Yubao, L., Xiaoming, Y. et al. Preparation and in vivo investigation of artificial cornea made of nano-hydroxyapatite/poly (vinyl alcohol) hydrogel composite. J Mater Sci: Mater Med 18, 635–640 (2007). https://doi.org/10.1007/s10856-007-2313-5
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s10856-007-2313-5