Skip to main content

Advertisement

Log in

Polyurethane/poly(hydroxyethyl methacrylate) semi-interpenetrating polymer networks for biomedical applications

  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

The thermodynamic miscibility, morphology, phase distribution, mechanical properties, surface properties, water sorption, bacterial adhesion and cytotoxicity of semi-interpenetrating polymer networks (semi-IPNs) based on crosslinked polyurethane (PU) and poly(hydroxyethylmethacrylate) (PHEMA) were studied to give an insight into their structure and properties.

The free energies of mixing of the two polymers in semi-IPNs have been determined and it was shown that the values are positive and depend on the amount of PHEMA. This demonstrates that the components are immiscible, the extent of which is dependent upon variations in composition.

The morphology of the semi-IPNs was analyzed with scanning electron microscopy and tapping mode atomic force microscopy (TMAFM). The micrographs of the semi-IPNs and TMAFM phase images indicated that distinct phase separation at the nanometer scale is observed.

The mechanical properties reflect the changes in structure of semi-IPNs with composition. The stress at break increases from 3.4 MPa to 23.9 MPa, and the Young’s modulus from 12.7 MPa up to 658.5 MPa with increasing amounts of PHEMA, but strain at break has a maximum at 40.4% PHEMA.

The bacterial adhesion and cytotoxicity data suggest that semi-IPNs with PHEMA content above 22% may be used for biomedical material applications.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. M. D. LEHAH and S. L. COOPER, in “Polyurethane in Medicine and Surgery” (CRC Press, Boca Raton, FL, 1986) p. 158.

    Google Scholar 

  2. R. W. PAYNTER, H. MARTZ and R. GUIDOIN, Biomaterials 94 (1987) 8.

    Google Scholar 

  3. R. J. THOMA, J. Biomater. Appl. 449 (1987) 1.

    Google Scholar 

  4. M. SZYCHER, D. DEMPSEY and V. L. POIRIER, Trans. Am. Soc. Biomater. 24 (1984) 7.

    Google Scholar 

  5. A. W. LLOYD, R. G. A. FARAGHER and S. P. DENYER, Biomaterials 769 (2001) 22.

    Google Scholar 

  6. A. B. LOWE, M. VAMVAKAKI, M. A. WASSALL, L. WONG, N. C. BILLINGHAM, S. P. ARMES and A. W. LLOYD, J. Biomed. Mat. Res. 88 (2000) 52.

    Google Scholar 

  7. L. H. SPERLING and V. MISRA, in “IPNs Around the World: Science and Engineering,” edited by S. C. Kim and L. H. Sperling (Wiley, 1997) p. 16.

  8. V. D. ATHAWALE, S. L. KOLEKAR and S. S. RAUT, J. Macromol. Sci., Part C-Polym Rev. 43 (2003) 1.

    Article  Google Scholar 

  9. L. H. SPERLING and R. HU, in “Polymer Blends Handbook,” edited by L. A. Utracki (Kluwer, Dordrecht, 2002) p. 56.

    Google Scholar 

  10. Yu. S. LIPATOV, in “Polymer Reinforcement” (Chem. Tec. Publ., Ontario, 1995) p. 286.

    Google Scholar 

  11. Y. S. LIPATOV and L. V. KARABANOVA, in “Advances in Interpenetrating Polymer Networks” (Technomic Publ. Company, Inc., Lancaster, 1994) p. 191.

    Google Scholar 

  12. Y. S. LIPATOV, in “Advances in Interpenetrating Polymer Networks,” edited by D. Klempner and K. Frisch (Technomic Publ. Company, Inc., Lancaster, 1989) p. 261.

    Google Scholar 

  13. L. V. KARABANOVA, P. PISSIS, A. KANAPITSAS and E. D. LUTSYK, J. Appl. Polym. Sci. 68 (1998) 161.

    Article  CAS  Google Scholar 

  14. Y. S. LIPATOV, L. V. KARABANOVA and L. M. SERGEEVA, Polym. Intern. 34 (1994) 7.

    Article  CAS  Google Scholar 

  15. Y. S. LIPATOV, G. M. SEMENOVICH, S. I. SKIBA, L. V. KARABANOVA and L. M. SERGEEVA, Polymer 33 (1992) 361.

    Article  CAS  Google Scholar 

  16. Y. S. LIPATOV, J. Macromol. Sci. Rev. Macromol. Chem. Phys. C30 (1990) 209.

    CAS  Google Scholar 

  17. Y. S. LIPATOV, L. V. KARABANOVA, L. A. GORBACH, E. D. LUTSYK and L. M. SERGEEVA, Polym. Intern. 28 (1992) 99.

    CAS  Google Scholar 

  18. L. V. KARABANOVA, G. BOITEUX, O. GAIN, G. SEYTRE, L. M. SERGEEVA and E. D. LUTSYK, J. Appl. Pol. Sci. 80 (2001) 852.

    Article  CAS  Google Scholar 

  19. J.-M. WIDMAIER and G. C. MEYER, in “Advances in Interpenetrating Polymer Networks,” edited by D. Klemper and K. Frisch (Technomic Publ. Company, Inc., Lancaster, 1989) Vol. 1, p. 155.

    Google Scholar 

  20. X. M. XU, H. TOGHIANI and C. U. PITTMAN, Polym. Eng. Sci. 40 (2000) 2027.

    Article  CAS  Google Scholar 

  21. K. H. HSIEH, C. C. TSAI and S. M. TSENG, J. Membr. Sci. 341 (1990) 49.

    Google Scholar 

  22. Y. OHTSUKA, Appl. Phys. 247 (1973) 23.

    Google Scholar 

  23. M. DROR, M. Z. ELSABEE and G. C. BERRY, Biomater. Med. Devices Artif. Organs 14 (1979) 7.

    Google Scholar 

  24. P. PREDECKI, J. Biomed. Mater. Res. 487 (1974) 8.

    Google Scholar 

  25. P. D. NAIR and V. N. KRISHNAMURTHY, J. Appl. Polym. Sci. 1321 (1996) 60.

    Google Scholar 

  26. A. A. TAGER, Vysokomol. Soed. 19 (1977) 1654.

    Google Scholar 

  27. L. E. NIELSEN, in “Mechanical Properties of Polymers and Composities”(Marcel Dekker, Inc., New York, 1974) p. 310.

    Google Scholar 

  28. J. D. ANDRADE, L. M. SMITH and D. E. GREGONIS, in “Surface and Interfacial Aspects of Biomedical Polymers,” edited by J.D. Andrade (Plenum Press, New York, 1985) Vol. 1, p. 249.

    Google Scholar 

  29. D. G. CASTNER and B. D. RATNER, Surf. Sci. 500 (2002) 28.

    Article  CAS  Google Scholar 

  30. L. V. KARABANOVA, S. V. MIKHALOVSKY, L. M. SERGEEVA, S. T. MEIKLE, M. HELIAS and A. W. LLOYD, Polym. Eng. Sci 44 (2004) 940.

    Article  CAS  Google Scholar 

  31. L. V. KARABANOVA, L. M. SERGEEVA, S. V. MIKHALOVSKY, J. SALVAGE, S. BUTLER and A. W. LLOYD, in Proceedings of the 9 International Conference “Polymers in Medicine and Surgery,” Krems, Austria, September 2000, p. 13.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. W. Lloyd.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Karabanova, L.V., Lloyd, A.W., Mikhalovsky, S.V. et al. Polyurethane/poly(hydroxyethyl methacrylate) semi-interpenetrating polymer networks for biomedical applications. J Mater Sci: Mater Med 17, 1283–1296 (2006). https://doi.org/10.1007/s10856-006-0603-y

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10856-006-0603-y

Keywords

Navigation