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Hydrogel-elastomer composite biomaterials: 2. Effects of aging methacrylated gelatin solutions on the preparation and physical properties of interpenetrating polymer networks

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Abstract

This study was conducted to understand the effects of aging methacrylated gelatin solutions on the properties of gelatin-HydroThaneTM Interpenetrating Polymer Network (IPN) films. The latter were prepared from methacrylated gelatin solutions that were either freshly made or stored at different concentrations and temperatures for various periods. The morphology, swelling stability and mechanical properties of the IPNs were then accordingly characterized. The IPNs prepared with aged solutions showed a reduced phase separation; changed from a network-like structure to a continuous phase structure; and demonstrated higher swelling stabilities and higher elasticity under optimal aging conditions, compared to the IPN prepared with a fresh methacrylated gelatin solution. An increase in viscosity and a change in phase transition of aged methacrylated gelatin solutions were also observed, presumably due to the physical structuring of methacrylated gelatin chains (e.g., by the formation of a helix structure), thus altering the resulting IPN characteristics. A better understanding of the effects of aging methacrylated gelatin solution on the formation and properties of gelatin-HydroThaneTM IPNs should enable us to further develop our composite biomaterials for different dressing applications.

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Acknowledgments

The authors are indebted to Defence Research and Development Canada for support.

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Authors and Affiliations

  1. Defence Research and Development Canada – Toronto, 1133 Sheppard Avenue West, P. O. Box 2000, Toronto, ON, Canada, M3M 3B9

    Henry T. Peng, Michelle Mok, Lucie Martineau & Pang N. Shek

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  1. Henry T. Peng
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  2. Michelle Mok
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  3. Lucie Martineau
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  4. Pang N. Shek
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Correspondence to Henry T. Peng.

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Peng, H.T., Mok, M., Martineau, L. et al. Hydrogel-elastomer composite biomaterials: 2. Effects of aging methacrylated gelatin solutions on the preparation and physical properties of interpenetrating polymer networks. J Mater Sci: Mater Med 18, 1025–1035 (2007). https://doi.org/10.1007/s10856-006-0072-3

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  • DOI: https://doi.org/10.1007/s10856-006-0072-3

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