Abstract
A new class of scaffolds with a gain size of 200 nm was prepared from wollastonite/tricalcium phosphate (WT) nanocomposite powders (termed “nano-sintered scaffolds”) through a two-step chemical precipitation and porogen burnout techniques. For a comparison, WT scaffolds with a grain size of 2 μm were also fabricated from submicron composite powders (termed “submicron-sintered scaffolds”) under the same condition. The resultant scaffolds showed porosities between 50 ± 1.0% and 65 ± 1.0% with a pore size ranging from 100 μm to 300 μm. The WT nano-sintered scaffolds exhibited compressive strength and elastic modulus values that were about twice that of their submicron-sintered counterparts. The in vitro degradation tests demonstrated that the degradability could be regulated by the grain size of bioceramics. The decreased specific surface area of pores in the nano-sintered scaffolds led to their reduced degradation rate. The mechanical properties of the nano-sintered scaffolds exhibited less strength loss during the degradation process. The WT macroporous nano-sintered scaffolds are a promising and potential candidate for bone reconstruction applications.
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Acknowledgements
The authors are grateful for the financial supports of the Science & Technology Commission of Shanghai Municipality of China (Project No. 0352nm119, No.05DJ14005), State 973 Program of China (Project No. 2005CB522704), Shanghai Postdoctoral Scientific Key Program (Project No. 06R214201), and China Postdoctoral Science Foundation (No. 20060390648). We would like to thank Mr. Lyndon F. Charles Jr. for his revision of the manuscript.
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Zhang, F., Chang, J., Lin, K. et al. Preparation, mechanical properties and in vitro degradability of wollastonite/tricalcium phosphate macroporous scaffolds from nanocomposite powders. J Mater Sci: Mater Med 19, 167–173 (2008). https://doi.org/10.1007/s10856-006-0056-3
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DOI: https://doi.org/10.1007/s10856-006-0056-3