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BCP ceramic microspheres as drug delivery carriers: synthesis, characterisation and doxycycline release

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Abstract

Resorbable ceramics such as biphasic calcium phosphates (BCP) are ideal candidates as drug delivery systems. The BCP ceramic is based on the optimum balance of the most stable hydroxyapatite (HA) phase and more soluble tricalcium phosphate phase (TCP). Doxycycline is a broad-spectrum antibiotic used for the local treatment of periodontitis. The development of BCP microspheres and its release kinetics with doxycycline have been studied. The BCP ceramic powder were prepared by microwave processing and characterised by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR) methods. The BCP microspheres were formed by liquid immiscibility effect using gelatin and paraffin oil. Difference in the morphology of the microspheres as a function of gelatin content has been observed. Scanning electron microscope indicated spherical and porous morphology of the microspheres. Drug incorporation was studied at varying pH and the pH 7 was found to be optimal for drug loading. Release pattern tend to depend on the morphology of BCP microspheres. An optimum release of 80% drug has been observed for BCP microsphere with HA:TCP = 65:35 ratio. The surface area measurement results also correlate with drug release obtained.

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References

  1. A. KRAJEWSKI, M. KIRSCH, A. RAVAGLIOLI, M. MAZZOCCHI in Proceedings of the 6th International Meeting and Seminar on Ceramics, Cells and Tissues. Faenza, 2000, edited by A. Ravaglioli, A.Krajewski p. 3.

  2. L. DI SILVIO and W. BONFIELD, J. Mater. Sci: Mater. Med. 10 (1999) 653

    Article  CAS  Google Scholar 

  3. W. PAUL and C. P. SHARMA, J. Biomaterial. Appl. 17 (2003) 253

    Article  CAS  Google Scholar 

  4. V. S. KOMLEV, S. M. BARINOV and E. V. KOPLIK, Biomaterials 23 (2002) 3449

    Article  CAS  Google Scholar 

  5. S. KIMAKHE, S. BOHIC, C. LAROSSE, A. REYNAUD, P. PILET, B. GIUMELLI, D. HEYMANN and G. DACULSI, J. Biomed. Mater. Res. 47 (1999) 18

    Article  CAS  Google Scholar 

  6. M. TREANT, J. GUICHEUX, G. GRIMANDS, M. LEROY and G. DACULSI, Biomaterials 18 (1997) 141

    Article  Google Scholar 

  7. L. OBADIA, G. AMADOR, G. DACULSI and J. M. BOULDER, Biomaterials 24 (2003) 1265

    Article  CAS  Google Scholar 

  8. L. E. BROMBERG, V. M. BRAMAN, D. M. ROTHSTEIN, P. SPACCIAPOLI, S. M. O’CONNOR, E. J. NELSON, D. K. BUXTON, M. S. TONETTI and P. M. FRIDEN, J. Control. Rel. 68 (2000) 63

    Article  CAS  Google Scholar 

  9. L. E. BROMBERG, D. K. BUXTON and P. M. FRIDEN, J. Control. Rel. 71 (2001) 251

    Article  CAS  Google Scholar 

  10. G. DACULSI, Biomaterials 19 (1998) 1473

    Article  CAS  Google Scholar 

  11. G. DACULSI, N. PASSUTTI, S. MARTIN, C. DEUDON, R. Z. LEGEROS and S. RATHER, J. Biomed. Mater. Sci. 24 (1990) 1623

    Article  Google Scholar 

  12. T. S. SAMPATH KUMAR, I. MANJUBALA and J. GUNASEKARAN, Biomaterials 21 (2000) 272

    Article  Google Scholar 

  13. I. MANJUBALA and M. SIVAKUMAR, Mater. Chem. Phys. 71 (2001) 379

    Google Scholar 

  14. MADHANA. SUNDER, N. RAMESH BABU, SUNITA PREM VICTOR, K. RAMKUMAR and T. S. SAMPATH KUMAR, Trends Biomat. Artif. Organs. 18 (2005) 213

    Google Scholar 

  15. D. M. LIN, S. KALACHANDRA, J. VALIAPARAMBIL and S. OFFENBACHER, Dental Mater. 19 (2003) 589

    Article  CAS  Google Scholar 

  16. M. STIGER, J. BEZEMER, K. DE GROOT and P. LAYROLLE, J. Control. Rel. 99 (2004) 127

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Metallurgical and Materials Engineering, Indian Institute of Technology, Madras, 600036, India

    Sunita Prem Victor & T. S. Sampath Kumar

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  1. Sunita Prem Victor
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  2. T. S. Sampath Kumar
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Correspondence to T. S. Sampath Kumar.

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Victor, S.P., Kumar, T.S.S. BCP ceramic microspheres as drug delivery carriers: synthesis, characterisation and doxycycline release. J Mater Sci: Mater Med 19, 283–290 (2008). https://doi.org/10.1007/s10856-006-0044-7

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  • DOI: https://doi.org/10.1007/s10856-006-0044-7

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