Abstract
To obtain bioceramics with good osteoinductive ability and mechanical strength, graded hydroxyapatite–zirconia (HA–ZrO2) composite bioceramics were prepared in this work. The biocompatibility of the bioceramics was investigated in vitro based on acute toxicity and cytotoxicity tests and hemolysis assay. Results showed the studied graded HA–ZrO2 had little toxicity to mouse and L929 mouse fibroblasts. Also, hemolysis assay indicated a good blood compatibility of the bioceramics. Based on the results of in vitro tests, animal experiments were performed on white New Zealand rabbits by implantation into hip muscles and femur. It was found that the graded HA–ZrO2 composite bioceramics exhibited superior osteoinductive ability, which may be a promising bioceramics implant.
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References
P. R. A. KUMAR, H. K. VARMA and T. V. KUMARY, Acta Biomater. 1 (2005) 545
R. KUMAR, P. CHEANG and K. A. KHOR, Biomaterials 24 (2003) 2611
H. W. KIM, Y. M. KONG, C. J. BAE, Y. J. NOH and H. E. KIM, Biomaterials 25 (2004) 2919
X. G. MIAO, Y. M. CHEN, H. B. GUO and K. A. KHOR, Ceram. Int. 30 (2004) 1793
V. V. SILVA, F. S. LAMEIRAS and R. Z. DOMINGUES, Compos. Sci. Technol. 61 (2001) 301
K. YOSHIDA, K. HASHIMOTO, Y. TODA, S. UDAGAWA and T. KANAZAWA, J. Eur. Ceram. Soc. 26 (2006) 515
R. KUMAR, P. CHEANG and K. A. KHOR, J. Mater. Proc. Technol. 140 (2003) 420
R. R. RAO and T. S. KANNAN, Mater. Sci. Eng. C 20 (2002) 187
M. SIVAKUMAR and I. MANJUBALA, Mater. Lett. 50 (2001) 199
B. Y. CHOU and E. CHANG, Scripta Mater. 45 (2001) 487
S. PADILLA, J. ROMAN, S. SANCHEZ-SALCEDO and M. VALLET-REGI, Acta Biomater. 2 (2006) 331
H. W. KIM and H. E. KIM, J. Biomed. Mater. Res. Part B 77B (2006) 323
Y. M. KONG, C. J. BAE, S. H. LEE, H. W. KIM and H. E. KIM, Biomaterials 26 (2005) 509
T. SUZUKI, S. FUJIBAYASHI, Y. NAKAGAWA, I. NODA and T. NAKAMURA, Biomaterials 27 (2006) 996
N. KAWASHIMA, K. SOETANTO, K. WATANABE, K. ONO and T. MATSUNO, Colloid Surf. B 10 (1997) 23
T. SUZUKI et al., J. Biosci. Bioeng. 89 (2000) 18
R. B. HEIMANN, H. KURZWEG, D. G. IVEY and M. L. WAYMAN, J. Biomed. Mater. Res. 43 (1998) 441
S. FOPPIANO, S. J. MARSHALL, E. SAIZ, A. P. TOMSIA and G. W. MARSHALL, Acta Biomater. 2 (2006) 133
E. S. AHN, N. J. GLEASON, A. NAKAHIRA and J. Y. YING, Nano Lett. 1 (2001) 149
M. INUZUKA, et al., Solid State Ionics 172 (2004) 509
V. V. SILVA, F. S. LAMEIRAS and R. Z. DOMINGUES, Ceram. Int. 27 (2001) 615
A. Y. SADL, M. A. SHOKRGOZAR, S. S. HOMAELGOHAR, M. HOSSELNALLPOUR, A. KHAVANDL and J. JAVADPOUR, J. Mater. Sci.: Mater. Med. 17 (2006) 407
H. SIMANK, M. STUBER, R. FRAHM, L. HELBIG, H. V. LENTHE and R. MULLER, Biomaterials 27 (2006) 3988
R. F. QUAN, D. S. YANG, X. C. WU, H. B. WANG, X. D. MIAO and W. LI, J. Biomater. Appl. in press
B. J. NABLO and M. H. SCHOENFISCH, Biomaterials 26 (2005) 4405
L.-S. WAN, Z.-K. XU, X.-J. HUANG, Z.-G. WANG and J.-L. WANG, Polymer 46 (2005) 7715
L.-S. WAN, Z.-K. XU, X.-J. HUANG, Z.-G. WANG and P. YE, Macromol. Biosci. 5 (2005) 229
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The financial support from the Ministry of Science and Technology of China is gratefully acknowledged.
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Quan, R., Yang, D., Wu, X. et al. In vitro and in vivo biocompatibility of graded hydroxyapatite–zirconia composite bioceramic. J Mater Sci: Mater Med 19, 183–187 (2008). https://doi.org/10.1007/s10856-006-0025-x
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DOI: https://doi.org/10.1007/s10856-006-0025-x