Skip to main content
SpringerLink
Log in

Preparation and characterization of pH sensitive comb-shaped chitosan material for the controlled release of coenzyme A

  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

A novel kind of pH sensitive comb-shaped copolymer P(CS-Ma-PEGMA) was synthesized with chitosan (CS), maleic anhydride (Ma) and Poly (ethylene glycol) methacrylate (PEGMA) by grafting and co-polymerization. The structure of P(CS-Ma-PEGMA) was characterized by FT-IR and 1H-NMR, and it was found that PEGMA was grafted onto CS and PEGMAylated chitosan was soluble. The copolymer was subjected to coenzyme A adsorption study in order to assess its application in biomedical area. The factors affecting release behavior, such as concentration and pH were discussed in this paper. The higher concentration of the copolymer showed higher absorbance peak than the lower one. The pH of the solution also had significant impact on the release of coenzyme A, and the mechanism of adsorption was suggested. The results suggested that the novel copolymer could be used as drug delivery carrier.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. L. CHU, T. NIITSUMA and T. YAMAGUCHI, AIChE. J. 49 (2003) 896

    Article  CAS  Google Scholar 

  2. W. SHIM, S. KIM and E. CHOI, Macromolec. Biosci. 6 (2006) 179

    Article  CAS  Google Scholar 

  3. J. CHRISTOPHE and A. JESSICA, J. Polym. Sci. Part B. 42 (2004) 3654

    Article  Google Scholar 

  4. M. CHIPARA and I. MORJAN, J. Polym. Sci. Part B. 43 (2005) 3432

    Article  CAS  Google Scholar 

  5. S. KIHLMAN and A. KROZER, J. Appli. Polym. Sci. 92 (2004) 2833

    Article  Google Scholar 

  6. P. VOS, G. CHRIS and J. HENK, Biomedic. Mater. Rese. 60 (2002) 252

    Article  Google Scholar 

  7. D. AMEYE, J. VOORSPOELS and P. FOREMAMN, J. Controlled Release 75 (2001) 357

    Article  CAS  Google Scholar 

  8. W. AMORNCHAI, P. VIPAVEE, Macromol.symp. 216 (2004) 99

    Article  CAS  Google Scholar 

  9. K. SUPRANEE and B. SIRIDECH, Euro. Polym. J. 42 (2006) 1609

    Article  Google Scholar 

  10. J. LIU, L. WU, J. YU and S. WANG, J. Donghua Univ. 4 (2003) 117

    Google Scholar 

  11. I. YOUNG and K. HONG, J Agric. Food chem. 46 (1998) 3839

    Article  Google Scholar 

  12. K. DINESH and R. ALOK, Macromol. Chem. Phys. 40 (2000) 69

    Google Scholar 

  13. K. INOMATA and E. NAKANISHI, J. Polym. Sci. Part B. 43 (2005) 79

    Article  CAS  Google Scholar 

  14. R. LANGER and A. NICHOLAS, AIChE J. 49 (2003) 2990

    Article  CAS  Google Scholar 

Download references

Acknowledgment

The authors are grateful to the National Natural Science Foundation of China (Grant Number: 50273010) for the support of this study.

Author information

Authors and Affiliations

  1. Institute of Fine Chemical and Engineering, Henan University, 85# Minglun Street, Kaifeng, Henan, 475001, P. R. China

    Baolin Guo, Jinfang Yuan & Qingyu Gao

Authors
  1. Baolin Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jinfang Yuan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Qingyu Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Qingyu Gao.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Guo, B., Yuan, J. & Gao, Q. Preparation and characterization of pH sensitive comb-shaped chitosan material for the controlled release of coenzyme A. J Mater Sci: Mater Med 18, 753–757 (2007). https://doi.org/10.1007/s10856-006-0017-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10856-006-0017-x

Keywords

Search

Navigation