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Sol-gel processing of drug delivery materials and release kinetics

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Abstract

Silica, calcium (5 mol%) silicate and silica/polycaprolactone hybrid inorganic/organic amorphous materials, all mixed with sodium ampicillin, a broad-spectrum antibiotic, have been synthesized by sol-gel method. The amorphous nature of the gels was ascertained by X-ray diffraction analysis. Release kinetics in a simulate body fluid (SBF) have been subsequently investigated. The amount of sodium ampicillin released has been detected by UV-Vis spectroscopy and SEM. The release kinetics seems to occur in more than one stage. Finally FTIR measurements and SEM micrograph showed the formation of a hydroxyapatite layer on the surface of the samples soaked in SBF. All data showed that these materials could be used as drug delivery bioactive systems.

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Author notes

  1. L. Ambrosio

    Present address: Institute of Composite and Biomedical Materials CNR, Interdisciplinary Research Centre in Biomaterials (CRIB), University of Naples “Federico II”Piazzale Tecchio 80, 80125, Naples, Italy

Authors and Affiliations

  1. Department of Materials and Productions Engineering, University of Naples “Federico II”Piazzale Tecchio, 80125, Naples, Italy

    F. De Gaetano, L. Ambrosio, M. G. Raucci, A. Marotta & M. Catauro

Authors
  1. F. De Gaetano
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  2. L. Ambrosio
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  3. M. G. Raucci
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  4. A. Marotta
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  5. M. Catauro
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Correspondence to F. De Gaetano.

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De Gaetano, F., Ambrosio, L., Raucci, M.G. et al. Sol-gel processing of drug delivery materials and release kinetics. J Mater Sci: Mater Med 16, 261–265 (2005). https://doi.org/10.1007/s10856-005-6688-x

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  • DOI: https://doi.org/10.1007/s10856-005-6688-x

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