Biological properties of the intervertebral cages made of titanium containing a carbon-carbon composite covered with different polymers

  • V Pešáková
  • K. SmetanaJr
  • M. Sochor
  • H. Hulejová
  • K. Balík


Intervertebral cages are used in orthopaedics for stabilization of injured lumbar parts of vertebral columns. Our study provides preliminary results of tests of the biological properties of titanium cages with a variously modified carbon/carbon composite (C/C) core. This core was produced from a C/C composite modified by hydrogel materials based on poly(2-hydroxyethyl methacrylate) (HEMA) enriched with 1% collagen or 35% methylmethacrylate or 30% terc-butylmethacrylamide.

We evaluated the adhesion of the cells to the tested material coating using an in vitro study of the metabolic activity and cytokine production of the cells (TNF-α, IL-8). We studied the biocompatibility of intervertebral cages coated with different copolymers under in vivo condition and in an implantation experiment in the porcine femurs.

Both in vitro and in vivo results revealed favourable biotolerance of the use system. Modification of the composite HEMA with the use of collagen seems to have a more positive effect on the new bone tissue formed around the implanted devices than HEMA copolymerized with methylmethacrylate or terc-butylmethacrylamide.


Polymer Titanium Cage Methacrylate Metabolic Activity 
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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • V Pešáková
    • 1
  • K. SmetanaJr
    • 2
  • M. Sochor
    • 3
  • H. Hulejová
    • 1
  • K. Balík
    • 4
  1. 1.Rheumatological Institute Na Slupi 4Prague 2Czech Republic
  2. 2.Department of AnatomyCharles University, Ist Medical Faculty, U nemocnice 3Prague 2Czech Republic
  3. 3.Department of MechanicsFaculty of Mechanical Emg. Czech Technical University, Technická 4Prague 6Czech Republic
  4. 4.Institute of Rock structure and MechanicsAcademy of Sciences of the Czech Republic VPrague 8Czech Republic

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