Skip to main content

Recent development of polymer nanofibers for biomedical and biotechnological applications

Journal of Materials Science: Materials in Medicine volume 16, pages 933–946 (2005)Cite this article

Abstract

Research in polymer nanofibers has undergone significant progress in the last one decade. One of the main driving forces for this progress is the increasing use of these polymer nanofibers for biomedical and biotechnological applications. This article presents a review on the latest research advancement made in the use of polymer nanofibers for applications such as tissue engineering, controlled drug release, wound dressings, medical implants, nanocomposites for dental restoration, molecular separation, biosensors, and preservation of bioactive agents.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

References

  1. A. J. MENEZES, V. J. KAPOOR, V. K. GOEL, B. D. CAMERON and J.-Y. LU, Mech. Engng, 2001, Aug: 54–58.

  2. T. GRAFE and K. GRAHAM, Intern. Nonwov. J. 12(1) (2003) 51.

    Google Scholar 

  3. Z. M. HUANG, Y. Z. ZHANG, S. RAMAKRISHNA and C. T. LIM, Polymer (2004) 45(15) 5361.

    Article  Google Scholar 

  4. D. H. RENEKER and I. CHUN, Nanotechnology 7(3) (1996) 216.

    Article  Google Scholar 

  5. Z. M. HUANG, Y. Z. ZHANG, M. KOTAKI and S. RAMAKRISHNA, Comp. Sci. Techn. 63 (2003) 2223.

    Article  Google Scholar 

  6. G. F. WARD, Filtration & Separation 38(9) (2001) 42.

    Google Scholar 

  7. B. GU, J. V. BADDING and A. SEN, Polym. Preprs. 44(2) (2003) 142.

    Google Scholar 

  8. P. X. MA and R. ZHANG, J. Biom. Mater. Res. 46(1) (1999) 60.

    Article  Google Scholar 

  9. F. YANG, R. MURUGAN, S. RAMAKRISHNA, X. WANG, Y.-X. MA and S. WANG, Biomaterials 25(10) (2004) 1891.

    Article  PubMed  Google Scholar 

  10. J. D. HARTGERINK, E. BENIASH and S. I. STUPP, Science 294(5547) (2001) 1684.

    Article  PubMed  Google Scholar 

  11. M. O. GULER, B. M. RABATIC, R. C. CLAUSSEN and S. I. STUPP, Polym. Prep. 44(2) (2003) 102.

    Google Scholar 

  12. Q. CHENG, Polym. Prep. 44(2) (2003) 87.

    Google Scholar 

  13. C. R. MARTIN, Chem. Mater. 8 (1996) 1739.

    Article  Google Scholar 

  14. L. FENG, S. LI, H. LI, J. ZHAI, Y. SONG, L. JIANG and D. ZHU, Angew Chem. Int. Ed. 41(7) (2002) 1221.

    Article  Google Scholar 

  15. G. LIU, L. QIAO and A. GUO, Macromolecules 29 (1996) 5508.

    Article  Google Scholar 

  16. X. YAN, G. LIU, F. LIU, B. Z. TANG, H. PENG, A. B. PAKHOMOV and C. Y. WONG, Angew. Chem. Int. Ed. 40(19) (2001) 3593.

    Article  Google Scholar 

  17. A. V. NEIMARK, K. G. KORNEV, P. I. RAVIKOVITCH and S. RUETSCH, Polym. Prepr. 44(2) (2003) 160.

    Google Scholar 

  18. IWGN, 1999: http://www.wtec.org/loyola/nano/IWGN.Research.Directions/

  19. R. G. FLEMMING, C. J. MURPHY, G. A. ABRAMS, S. L. GOODMAN and P. F. NEALEY, Biomaterials 20(6) (1999) 573.

    Article  PubMed  Google Scholar 

  20. T. A. DESAI, Med. Eng. & Physics 22 (2000) 595.

    Google Scholar 

  21. A. CURTIS and C. WILKINSON, Trends Biotechn. 19(3) (2001) 97.

    Article  Google Scholar 

  22. H. G. CRAIGHEAD, C. D. JAMES and A. M. P. TURNER, Curr. Opin. Solid State Mater. Sci. 5 (2001) 177.

    Article  Google Scholar 

  23. C. T. LAURENCIN, A. M. AMBROSIO, M. D. BORDEN and J. A. COOPER JR., Ann. Rev. Biomed. Engng. 1 (1999) 19.

    Article  Google Scholar 

  24. J. S. STEPHENS, C. L. CASPER, D. B. CHASE and J. F. RABOLT, Polym. Prepr. 44(2) (2003) 91.

    Google Scholar 

  25. C. MIGLIARESI and L. FAMBRI, Macromol. Symp. 123 (1997) 155.

    Google Scholar 

  26. A. FERTALA, W. B. HAN and F. K. KO, J. Biomed. Mater. Res. 57(1) (2001) 48.

    Article  PubMed  Google Scholar 

  27. W. J. LI, C. T. LAURENCIN, E. J. CATERSON, R. S. TUAN and F. K. KO, J. Biomed. Mater. Res. 60(4) (2002) 613.

    Article  PubMed  Google Scholar 

  28. W. J. LI, K. G. DANIELSON, P. G. ALEXANDER and R. S. TUAN, J. Biomed. Mater. Res. 67A(4) (2003) 1105.

    Article  Google Scholar 

  29. H. YOSHIMOTO, Y. M. SHIN, H. TERAI and J. P. VACANTI, Biomaterials 24 (2003) 2077.

    Article  PubMed  Google Scholar 

  30. L. HUANG, R. A. MCMILLAN, R. P. APKARIAN, B. POURDEYHIMI, V. P. CONTICELLO and E. L. CHAIKOF, Macromolecules 33(8) (2000) 2989.

    Article  Google Scholar 

  31. K. NAGAPUDI, W. T. BRINKMAN, J. E. LEISEN, L. HUANG, R. A. MCMILLAN, R. P. APKARIAN, V. P. CONTICELLO and E. L. CHAIKOF, Macromolecules 35(5) (2002) 1730.

    Article  Google Scholar 

  32. C. Y. XU, R. INAI, M. KOTAKI and S. RAMAKRISHNA, Biomaterials 25 (2004) 877.

    Article  PubMed  Google Scholar 

  33. X. M. MO, C. Y. XU, M. KOTAKI and S. RAMAKRISHNA, Biomaterials 25(10) (2004) 1883.

    Article  PubMed  Google Scholar 

  34. X. ZONG, H. BIEN, C. Y. CHUNG, L. YIN, K. KIM, D. F. FANG, B. CHU, B. S. HSIAO and E. ENTCHEVA, Polym. Prepr. 44(2) (2003) 96.

    Google Scholar 

  35. G. A. SILVA, C. CZEISLER, K. L. NIECE, E. BENIASH, D. HARRINGTON, J. A. KESSLER and S. I. STUPP, Science 303(5662) (2004) 1352.

    Article  PubMed  Google Scholar 

  36. S. E. DABNEY, The Use of Electrospinning Technology to Produce Wound Dressings, PhD Dissertation, The University of Akron, May, 2002.

  37. J. A. MATTHEWS, G. E. WNEK, D. G. SIMPSON and G. L. BOWLIN, Biomacromolecules 3(2) (2002) 232.

    Article  PubMed  Google Scholar 

  38. S. S. KHAN, A. FERTALA and F. KO, Polym. Prepr. 44(2) (2003) 88.

    Google Scholar 

  39. J. A. MATTHEWS, E. D. BOLAND, G. E. WNEK, D. G. SIMPSON and G. L. BOWLIN, J. Bioact. Comp. Polym. 18 (2003) 125.

    Article  Google Scholar 

  40. Y. K. LUU, K. KIM, B. S. HSIAO, B. CHU and M. HADJIARGYROU, J. Contr. Rele. 89 (2003) 341.

    Article  Google Scholar 

  41. H.-J. JIN, J. CHEN, V. KARAGEORGIOU, G. H. ALTMAN and D. L. KAPLAN, Mat. Res. Soc. Symp. Proc. 735 (2003) C11.12.1.

  42. B.-M. MIN, G. LEE, S. H. KIM, Y. S. NAM, T. S. LEE and W. H. PARK, Biomaterials 25 (2004) 1289.

    Article  PubMed  Google Scholar 

  43. Y. Z. ZHANG, H. W. OUYANG, C. T. LIM, S. RAMAKRISHNA and Z. M. HUANG, J. Biomed. Mater. Res. Part B: Appl. Biomater. 72B(1) (2005) 156.

    Article  Google Scholar 

  44. A. THERON, E. ZUSSMAN and A. L. YARIN, Nanotechnology 12 (2001) 384.

    Article  Google Scholar 

  45. M. HADJIARGYROU, F. LOMBARDO, S. ZHAO, W. AHRENS, J. JOO, H. AHN, M. JURMAN, D. W. WHITE and C. T. RUBIN, J. Biol. Chem. 277 (2002) 30177.

    Article  PubMed  Google Scholar 

  46. A. SUTHAT and G. CHASE, Chem. Engng. (2001) Dec: 26–28.

  47. K. GRAHAM, M. OUYANG, T. RAETHER, T. GRAFE, B. MCDONALD and P. KNAUF, Polymer Nanofibers in Air Filtration Applications, Fifteenth Annual Technical Conference & Expo of the American Filtration & Separations Society, Galveston, Texas, 9–12 April, 2002.

  48. J. A. CARNEGIE and O. CABACA, Biol Reprod. 48 (1993) 287.

    PubMed  Google Scholar 

  49. F. IGNATIOUS and J. M. BALDONI, Electrospun Pharmaceutical Compositions, PCT/US01/02399.

  50. E-R. KENAWY, G. L. BOWLIN, K. MANSFIELD, J. LAYMAN, D. G. SIMPSON, E. H. SANDERS and G. E. WNEK, J. Contr. Rel. 81 (2002) 57.

    Article  Google Scholar 

  51. X. ZONG, K. KIM, J. CHIU, B. S. HSIAO, B. CHU, S. LI, B. GARLICK, C. BRATHWAITE, T. ZIMMERMAN and D. FANG, Polym. Prepr. 44(2) (2003) 89.

    Google Scholar 

  52. G. VERRECK, I. CHUN, J. PEETERS, J. ROSENBLATT and M. E. BREWSTER, Pharm. Res. 20(5) (2003) 810.

    Article  PubMed  Google Scholar 

  53. G. VERRECK, I. CHUN, J. ROSENBLATT, J. PEETERS, A. V. DIJCK, J. MENSCH, M. NOPPE and M. E. BREWSTER, J. Contr. Rel. 92 (2003) 349.

    Article  Google Scholar 

  54. J. ZENG, X. XU, X. CHEN, Q. LIANG, X. BIAN, L. YANG and X. JING, J. Contr. Rel. 92 (2003) 227.

    Article  Google Scholar 

  55. I. G. LOSCERTALES, A. BARRERO, I. GUERRERO, R. CORTIJO, M. MARQUEZ and A. M. GA NAN-CALVO, Science 295 (2002) 1695.

    Article  PubMed  Google Scholar 

  56. Z. M. HUANG, C. L. HE, A. YANG, Y. Z. ZHANG, X. J. HAN, J. YIN and Q. WU, J. Biomed. Mater. Res. Part A (submitted).

  57. S. THOMAS, “Wound Management and Dressings,” (Pharmaceutical Press, London. 1990).

  58. R. A. COFFEE, A Dispensing Device and Method for Forming Material, PCT International Application No: PCT/GB97/01968, 1998

  59. D. SMITH, D. RENEKER, A. MCMANUS, H. SCHREUDER-GIBSON, C. MELLO, M. SENNETT and P. GIBSON, Electrospun Fibers and an Apparatus Therefore, PCT International Application No: PCT/US00/27776, 2001.

  60. G. E. WNEK, M. E. CARR, D. G. SIMPSON and G. L. BOWLIN, Nano Lett. 3(2) (2003) 213.

    Article  Google Scholar 

  61. E-R. KENAWY, J. M. LAYMAN, J. R. WATKINS, G. L. BOWLIN, J. A. MATTHEWS, D. G. SIMPSON and G. E. WNEK, Biomaterials 24 (2003) 907.

    Article  PubMed  Google Scholar 

  62. J. M. LAYMAN, I-R. KENAWY, J. R. WATKINS, M. E. CARRJR., G. BOWLIN and G. E. WNEK, Polymer Preprints 44(2) (2003) 94.

    Google Scholar 

  63. M-S. KHIL, D-I. CHA, H-Y. KIM, I-S. KIM and N. BHATTARAI, J. Biomed. Mater. Res. Part B: Appl Biomater, 67B (2003) 675.

  64. J. VALENTINE, S. BLOCKER and J. H. CHANG, J. Trauma 24(11) 1984 952.

    Google Scholar 

  65. G. E. MARTIN and I. D. COCKSHOTT, Fibrillar Product of Electrostatically Spun Organic Material, US Patent 4043331 (1977).

  66. D. MARTINDALE, Sci. Amer. July 2000: 34–36.

  67. D. SMITH, D. RENEKER, W. KATAPHINAN and S. DABNEY, Electrospun Skin Masks and Uses Thereof, PCT/US00/27775, 2001.

  68. G. E. MARTIN, I. D. COCKSHOTT and F. J. T. FILDES, Fibrillar Lining for Prosthetic Device, US Patent 4044404, 1977.

  69. G. E. MARTIN, I. D. COCKSHOTT and F. J. T. FILDES, Fibrillar Product, US Patent 4552707, 1985.

  70. How TV, Synthetic Vascular Grafts, and Methods of Manufacturing Such Grafts, US Patent 4552707, 1985.

  71. A. BORNAT, Production of Electrostatically Spun Products, US Patent 4689186, 1987.

  72. J. P. BERRY, Electrostatically Produced Structures and Methods of Manufacturing, US Patent 4965110, 1990.

  73. M. D. STENOIEN, W. J. DRASLER, R. J. SCOTT and M. L. JENSON, Silicone Composite Vascular Graft, US Patent 5866217, 1999.

  74. L. PINCHUK, J. B. MARTIN JR and A. A. MAURIN, Breast prostheses, US Patent 5376117, 1994.

  75. C. J. BUCHKO, L. C. CHEN, Y. SHEN and D. C. MARTIN, Polymer 40 (1999) 7397.

    Article  Google Scholar 

  76. C. J. BUCHKO, M. J. SLATTERY, K. M. KOZLOFF and D. C. MARTIN, J. Mater. Res. 15(1) (2000) 231.

    Google Scholar 

  77. C. J. BUCHKO, K. M. KOZLOFF and D. C. MARTIN, Biomaterials 22(11) (2001) 1289.

    Article  PubMed  Google Scholar 

  78. S. A. ATHREYA and D. C. MARTIN, Sensors and Actuators 72 (1999) 203.

    Article  Google Scholar 

  79. D. MENZIES, Surg. Ann. 24 (1992) 27.

    Google Scholar 

  80. X. ZONG, K. KIM, D. FANG, S. RAN, B. S. HSIAO and B. CHU, Polymer 43(16) (2002) 4403.

    Article  Google Scholar 

  81. H. FONG, Polym. Prepr. 44(2) (2003) 100.

    Google Scholar 

  82. J-S. KIM and D. H. RENEKER, Polym. Comp. 20(1) (1999) 124.

    Article  Google Scholar 

  83. Y. A. DZENIS and D. H. RENEKER, Delamination Resistant Composites Prepared by Small Diameter Fiber Reinforcement at Ply Interfaces, US Patent No. 626533, 2001.

  84. C. Y. K. TEO, K. FUJIHARA, V. K. GANESH, P. L. LOH, S. RAMAKRISHNA and C. L. CHEW, Fracture Resistance of Tie-Wing of Braided Composite Orthodontic Brackets, Submitted to Dental Materials, 2004.

  85. M. M. BERGSHOEF and G. J. VANCSO, Transparent Nanocomposites with Ultrathin, Electrospun Nylon-4,6 Fiber Reinforcement, Adv. Mater. 11(16) (1999) 1362.

    Google Scholar 

  86. P. GIBSON, H. SCHREUDER-GIBSON and D. RIVIN, Coll. Surf. A: Physicochem. Engng. Asp. 187 (2001) 469.

    Article  Google Scholar 

  87. H. SCHREUDER-GIBSON, P. GIBSON, K. SENECAL, M. SENNETT, J. WALKER, W. YEOMANS, D. ZIEGLER and P. P. TSAI, J. Adv. Mater. 34(4) (2002) 44.

    Google Scholar 

  88. Z. XU, J. F. VETELINO, R. LEC and D. C. PARKER, J. Vacuum Sci. Techn. A (Vacuum, Surfaces, and Films) 8(4) (1990) 3634.

    Google Scholar 

  89. S. J. KWOUN, R. M. LEC, B. HAN and F. K. KO, in The 2000 IEEE/EIA International Frequency Control Symposium and Exhibition, 7-9 June, 2000, at The Westin Crown Center, Kansas City, Missouri, USA.

  90. S. J. KWOUN, R. M. LEC, B. HAN and F. K. KO, in The IEEE 27th Annual Northeast Bioengineering Conference, March 31 - April 1, 2001, at University of Connecticut, Storrs, CT 06269, USA.

  91. X. WANG, C. DREW, S-H. LEE, K. J. SENECAL, J. KUMA and L. A. SAMUELSON, Nano Lett. 2(11) (2002) 1273.

    Article  Google Scholar 

  92. X. WANG, Y-G. KIM, C. DREW, B-C. KU, J. KUMAR and L. A. SAMUELSON, Nano Lett. 4(2) (2004) 331.

    Article  Google Scholar 

  93. S. H. LEE, B-C. KU, X. WANG, L. A. SAMUELSON and J. KUMAR, Design, Mat. Res. Soc. Symp. Pro. 708 (2002) BB10.45.1-BB10.45.6.

  94. H. NAKAMURA and I. KARUBE, Anal. Bioanal. Chem. 377 (2003) 446.

    Article  PubMed  Google Scholar 

  95. H. JIA, G. ZHU, B. VUGRINOVICH, W. KATAPHINAN, D. H. RENEKER and P. WANG, Biotechn. Progr. 18(5) (2002) 1027.

    Article  Google Scholar 

  96. D. SMITH, W. KATAPHINAN, D. RENEKER and S. DABNEY, Preservation of Biological Materials Using Fiber-Forming Techniques, PCT/US02/18380, 2002.

Download references

Author information

Affiliations

  1. Division of Bioengineering, National University of Singapore, Singapore, 117576

    Yanzhong Zhang, Chwee Teck Lim & Seeram Ramakrishna

  2. Department of Mechanical Engineering, National University of Singapore, Singapore, 117576

    Yanzhong Zhang, Chwee Teck Lim & Seeram Ramakrishna

  3. Nanoscience and Nanotechnology Initiative, National University of Singapore, Singapore, 117576

    Chwee Teck Lim & Seeram Ramakrishna

  4. Key Laboratory for Solid Mechanics of MOE, School of Aeronautics, Astronautics & Mechanics, Tongji University, Shanghai, 200092, People’s Republic of China

    Zheng-Ming Huang

Authors
  1. Yanzhong Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chwee Teck Lim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Seeram Ramakrishna
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Zheng-Ming Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zheng-Ming Huang.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Zhang, Y., Lim, C.T., Ramakrishna, S. et al. Recent development of polymer nanofibers for biomedical and biotechnological applications. J Mater Sci: Mater Med 16, 933–946 (2005). https://doi.org/10.1007/s10856-005-4428-x

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10856-005-4428-x

Keywords

  • Polymer
  • Drug Release
  • Tissue Engineering
  • Significant Progress
  • Drive Force