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Dynamic study of calcium phosphate formation on porous HA/TCP ceramics

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An Erratum to this article was published on 15 August 2008

Abstract

Bone-like apatite formation on porous calcium phosphate ceramics was investigated in static simulated body fluid (SBF) and dynamic SBF at different flowing rates. The results of a 14-day immersion in static SBF showed that the formation of bone-like apatite occurred both on the surface and in the pores of the samples. When SBF flowed at the physiological flow rate in muscle (2 ml/100 ml⋅min), bone-like apatite could be detected only in internal surface of the pores of samples. The result that bone-like apatite formation could only be found in the pores when SBF flowed at physiological flow rate was consistent with that of porous calcium phosphate ceramics implanted in vivo: osteoinduction was only detected inside the pores of the porous calcium phosphate ceramics. This result implicates that the bone-like apatite may play an important role in the osteoinduction of Ca-P materials. The dynamic model used in this study may be better than usually used static immersion model in imitating the physiological condition of bone-like apatite formation. Dynamic SBF method is very useful to understand bone-like apatite formation in vivo and the mechanism of ectopic bone formation in calcium phosphate ceramics.

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Authors and Affiliations

  1. State key Laboratory for Modification of Chemical Fibers and Polymer Material, Donghua University, Shanghai, 200051, People’s Republic of China

    Y. R. Duan

  2. West China School of Pharmacy, Sichuan University, Chengdu, 610041, People’s Republic of China

    Y. R. Duan & Z. R. Zhang

  3. Engineering Research Center in Biomaterials, Sichuan University, Chengdu, 610064, People’s Republic of China

    C. Y. Wang, J. Y. Chen & X. D. Zhang

Authors
  1. Y. R. Duan
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  2. Z. R. Zhang
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  3. C. Y. Wang
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  4. J. Y. Chen
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  5. X. D. Zhang
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Correspondence to J. Y. Chen.

Additional information

An erratum to this article is available at http://dx.doi.org/10.1007/s10856-008-3532-0.

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Duan, Y.R., Zhang, Z.R., Wang, C.Y. et al. Dynamic study of calcium phosphate formation on porous HA/TCP ceramics. J Mater Sci: Mater Med 16, 795–801 (2005). https://doi.org/10.1007/s10856-005-3577-2

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  • DOI: https://doi.org/10.1007/s10856-005-3577-2

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