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One-step synthesis of molecularly imprinted fluorescent sensors for highly selective detection of nicotinamide mononucleotide

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Abstract

A one-step approach was employed to synthesize fluorescent molecularly imprinted polymers (MIP@QDs) using CdSe quantum dots modified with sulfhydryl groups as the fluorescent core. Nicotinamide mononucleotide (NMN) was utilized as the template, methacrylic acid served as the functional monomer, and N,N′-methylenebisacrylamide functioned as the crosslinker for precipitation polymerization. Fluorescence quenching of the MIP@QDs enabled the quantitative detection of NMN. Within the concentration range of 0–100 µg·mL−1, the fluorescence intensity of the MIP@QDs decreased with increasing NMN concentration, with a detection limit of 0.0692 µg·mL−1. The MIP@QDs displayed superior selectivity for NMN compared with its structural analogues. Furthermore, application of the MIP@QDs to actual broccoli samples resulted in an NMN recovery rate ranging from 93.25 to 96.20%, with a relative standard deviation of 3.65–4.55%. This study provides a method for the facile preparation of fluorescent sensors based on precipitation polymerization, enabling rapid identification and quantification of NMN in complex matrices.

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Data availability

The authors declare that the data supporting the findings of this study are available within the paper. Should any raw data files be needed in another format they are available from the corresponding author upon reasonable request.

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Funding

This work was financially supported by the Key Research Projects of the acknowledgement Shaanxi Provincial Education Department (22JS002) and the Graduate Innovation Fund Project of Shaanxi University of Technology (SLGYCX2226).

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Authors and Affiliations

  1. School of Chemical & Environment Science, Shaanxi University of Technology, Hanzhong, 723001, Shaanxi, People’s Republic of China

    Li Xie, Meng Zhang, Yingchun Wu, Haitao Xiong & liang hao

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  1. Li Xie
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  2. Meng Zhang
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Contributions

LX: methodology, investigation, data curation, writing—original draft, writing—review and editing. MZ: methodology, investigation, data curation. YW: conceptualization, methodology, writing—review and editing, formal analysis, project administration, funding acquisition. HX: Writing—review and editing. LH: conceptualization, methodology and investigation.

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Correspondence to Yingchun Wu.

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Xie, L., Zhang, M., Wu, Y. et al. One-step synthesis of molecularly imprinted fluorescent sensors for highly selective detection of nicotinamide mononucleotide. J Mater Sci: Mater Electron 35, 311 (2024). https://doi.org/10.1007/s10854-024-12058-w

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