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Design of the polyacrylonitrile-reduced graphene oxide nanocomposite-based non-enzymatic electrochemical biosensor for glucose detection

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Abstract

With the advantages of developed electronic devices, various biosensor applications have become attractive issues with excellent electrochemical performances against biomarkers and molecules in biomedical applications. In this study, novel polyacrylonitrile (PAN)-reduced graphene oxide (rGO) nanocomposite-based non-enzymatic electrochemical biosensors were prepared to investigate the detection performance of the glucose. The PAN-rGO nanocomposite-based biosensor detected glucose with a high sensitivity and stability due to enhanced redox mechanism arising from rGO additive. PAN-rGO nanocomposite-based biosensor detected glucose in (0.75–12) mM with a high sensitivity of 49 µAmM−1 cm−2 (2.5 times higher than PAN-based sensor). Concentration–response graphs correlating the non-enzymatic electrochemical signal to glucose concentration revealed a low limit of detection (LOD) of 0.6 mM within 1-min voltammetric cycle. The selectivity results confirmed a significant preferential response of the proposed PAN-rGO nanocomposite-based biosensor for glucose against possible interfering compounds. The proposed PAN-rGO nanocomposite-based biosensor has a great potential to be used as a nanostructured platform for detection of glucose in phosphate-buffered saline (pH 7.4) solution with high sensitivity, selectivity, stability, reproducibility, and fast response properties.

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Data availability

The authors confirm that the data supporting the findings of this study are available within the article. Raw data that support the findings of this study are available from the corresponding author, upon reasonable request.

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Acknowledgements

This research was supported by TUBITAK Project 216M421.

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Authors and Affiliations

  1. Department of Chemistry, Istanbul University-Cerrahpasa, Istanbul, Turkey

    Selcan Karakuş

  2. TUBITAK Marmara Research Center, Materials Institute, Gebze, Kocaeli, Turkey

    Cihat Taşaltın & İlke Gürol

  3. CONSENS Inc., Maltepe University Research Center, Technopark, Maltepe University, Istanbul, Turkey

    Gülsen Baytemir & Nevin Taşaltın

  4. Department of Basic Sciences, Maltepe University, Istanbul, Turkey

    Nevin Taşaltın

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  1. Selcan Karakuş
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  2. Cihat Taşaltın
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  4. Gülsen Baytemir
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  5. Nevin Taşaltın
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Contributions

SK contributed to conceptualization, methodology, and writing—original draft preparation. CT contributed to  software and analysis. İG and GB contributed to analysis. NT contributed to conceptualization, methodology, writing—reviewing, and editing.

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Correspondence to Selcan Karakuş or Nevin Taşaltın.

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Karakuş, S., Taşaltın, C., Gürol, İ. et al. Design of the polyacrylonitrile-reduced graphene oxide nanocomposite-based non-enzymatic electrochemical biosensor for glucose detection. J Mater Sci: Mater Electron 33, 18400–18409 (2022). https://doi.org/10.1007/s10854-022-08694-9

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  • DOI: https://doi.org/10.1007/s10854-022-08694-9

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