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Electrochemical determination of levofloxacin with a Cu–metal–organic framework derivative electrode

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Abstract

Levofloxacin (LEV) is used in pharmaceuticals to treat bacterial infections, but is rarely metabolized by the human body, and hence, largely excreted. This leads to its accumulation in sewage, posing hazards to human health and the environment. Considering the drawbacks of existing methods to detect LEV, including a high cost, significant analysis time, and complex sample processing, the aim of this study was to devise an optimal detection method for LEV. A modified screen-printed electrode (SPE) using a Cu–metal–organic framework (MOF) derivative was proposed as an electrochemical sensor for LEV detection. They were characterized by transmission electron microscopy (TEM) and X-ray diffraction (XRD). The prepared Cu-MOF derivative offered a large specific surface area and highly dispersed active sites, which facilitated full contact with LEV. The electrochemical behavior of LEV was evaluated using cyclic voltammetry (CV) in the potential range of − 0.2 to 1 V. The linear response range was 0.1–100 μM, sensitivity was 1855 μA.mM−1.cm−2, and detection limit was 0.016 μM. The detection limit and sensitivity of differential pulse voltammetry (DPV) were 0.17 μM and 183 μA.mM−1.cm−2, respectively. The detection limit and sensitivity of chronoamperometry (CA) were 0.037 μM and 825 μA.mM−1.cm−2, respectively. The method exhibited significant selectivity and stability. The use of this electrochemical sensor containing the Cu-MOF derivative constitutes a simple and rapid method for determining LEV in medicine and the food industry.

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Acknowledgements

We acknowledge the support by Tianjin Natural Science Foundation (Grant No. 18JCZDJC99800), National Natural Science Foundation of China (Grant No. 51502203), Tianjin Distinguished Professor Foundation of Young Researcher, Tianjin Development Program for Innovation and Entrepreneurship, for research conducted at Tianjin University of Technology. The Ministry of Education (MOE2018-T2-2-095), for research conducted at the National.

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Authors and Affiliations

  1. School of Integrated Circuit Science and Engineering, Advanced Materials and Printed Electronics Center, Tianjin Key Laboratory of Film Electronic & Communication Devices, Tianjin University of Technology, Tianjin, 300384, China

    Jie Zhou, Peng Pan, Tong Li, Zhengchun Yang, Peng Li, Guanying Liu, Haodong Shen & Xiaodong Zhang

  2. School of Electrical Engineering and Automation, Tianjin University of Technology, Tianjin, 300384, China

    Jun Liu

  3. School of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen, 518055, China

    Jun Wei

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  1. Jie Zhou
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Contributions

All authors contributed to the study conception and design. JZ, JL, PP, TL, ZY, PL, GL, HS and XZ: Material preparation, data collection and analysis were performed. JZ: The first draft of the manuscript was written and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Jun Liu or Peng Pan.

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Zhou, J., Liu, J., Pan, P. et al. Electrochemical determination of levofloxacin with a Cu–metal–organic framework derivative electrode. J Mater Sci: Mater Electron 33, 9941–9950 (2022). https://doi.org/10.1007/s10854-022-07985-5

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