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Development of organic dosimeters based on fluorescence of radiation reaction products of coumarin-3-carboxylic acid

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Abstract

We developed organic materials that can be used as tissue-equivalent dosimeters. We focused on radiation-induced reactions of a water-soluble coumarin derivative, coumarin-3-carboxyl acid (C3CA). C3CA was added to polyvinyl chloride (PVC), polymethyl methacrylate (PMMA), and polyvinyl alcohol (PVA); the photoluminescence spectra of each polymer containing C3CA before and after X-ray irradiation were measured; their sensitivities to X-rays were compared based on changes in their fluorescence intensity. The fluorescent molecules were produced from C3CA upon X-ray irradiation of the three types of polymers. The materials based on PVC, PMMA, and PVA were sensitive to X-rays for doses up to 400 Gy, 8 kGy, and 1 kGy, respectively. These results suggest that the radicals produced from the polymers upon irradiation were added to coumarin. Furthermore, the addition of trichloroacetic acid enhanced the dose sensitivity of the PMMA-based samples. These results indicate that radiation-induced reactions of C3CA can be utilized as tissue-equivalent dosimeters and PVC is the best polymer for this material because of its high dose sensitivity. The difference in the G values and the reactivity of radicals produced in the polymers contributes to the difference in dose sensitivities.

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Acknowledgements

This research was supported by a Grant-in-Aid for Scientific Research (A) (No. 19H00880, 2018–2021). Part of this research is based on the Cooperative Research Project of the Research Center for Biomedical Engineering, Ministry of Education, Culture, Sports, Science, and Technology.

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Authors and Affiliations

  1. Department of Applied Chemistry, Tohoku University, 6-6-07 Aoba, Aramaki, Aoba-ku, Sendai, 980-8579, Japan

    Ritsuha Tanaka, Masanori Koshimizu, Ichiro Kawamura, Yutaka Fujimoto & Keisuke Asai

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  1. Ritsuha Tanaka
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  2. Masanori Koshimizu
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  3. Ichiro Kawamura
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  4. Yutaka Fujimoto
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  5. Keisuke Asai
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Contributions

Writing and preparation of the original draft and investigation was done by RT; conceptualization, methodology, validation, formal analysis, writing, reviewing, and editing of the manuscript, supervision, project administration, and funding acquisition was done by MK; investigation was done by IK; and writing, reviewing, and editing of the manuscript, supervision, and project administration was done by YF and KA. All the authors have read the manuscript and have approved this submission.

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Correspondence to Ritsuha Tanaka.

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Tanaka, R., Koshimizu, M., Kawamura, I. et al. Development of organic dosimeters based on fluorescence of radiation reaction products of coumarin-3-carboxylic acid. J Mater Sci: Mater Electron 33, 3938–3948 (2022). https://doi.org/10.1007/s10854-021-07588-6

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  • DOI: https://doi.org/10.1007/s10854-021-07588-6

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