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Structural and antioxidant properties of guanylhydrazinium pyrazine-2-carboxylate

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Abstract

In general, molecules with certain functional groups such as amine (-NH2) and carboxyl (-COOH) can promote the growth of co-crystals leading to the formation of supramolecular networks. However, if the differences in the pKa values of the two molecules are large [pKa (base)—pKa (acid)], salts can result instead of ‘real’ co-crystals. Here, we report the formation of such salt by letting pyrazine-2-carboxylic acid (pKa = 2.9) crystallize together with aminoguanidine (pKa = 11.5; high Δpka = 8.6) a nitrogen-rich organic base. The title salt has been prepared by slow evaporation of an equimolar ratio of guanylhydrazine bicarbonate (i.e., aminoguanidine bicarbonate (AgunH.HCO3)) and pyrazine-2-carboxylic acid (Pymca) in aqueous medium. The salt was characterized by IR spectroscopy, powder and single-crystal X-ray diffraction techniques. This material shows enhanced antioxidant activity and this is due to the crucial role of hydrazinic moiety in the aminoguanidinium salt.

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Acknowledgements

S. P. and L. K wishes to thank URF for the award of a research fellowship in science for meritorious students under the University Research Fellowship. The author S. G. thanks the UGC-SAP-DRS II, New Delhi (India), for financial support. S. G. is also thankful for the award of UGC-Emeritus Fellowship by UGC, New Delhi, India.

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Authors and Affiliations

  1. Science and Humanities (Chemistry), Sri Krishna College of Engineering & Technology, Coimbatore, 641 008, India

    S. Packiaraj

  2. Department of Chemistry, Bharathiar University, Coimbatore, 641 046, India

    S. Packiaraj, A. Pushpaveni, S. Poornima & S. Govindarajan

  3. Department of Botany, Nirmala College for Women, Coimbatore, 641 018, India

    L. Kousalya

  4. Department of Chemistry, Kongunadu Arts and Science College, Coimbatore, 641 029, India

    A. Pushpaveni

  5. Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK

    H. Puschmann

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Packiaraj, S., Kousalya, L., Pushpaveni, A. et al. Structural and antioxidant properties of guanylhydrazinium pyrazine-2-carboxylate. J Mater Sci: Mater Electron 32, 7704–7718 (2021). https://doi.org/10.1007/s10854-021-05489-2

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