Development of a quartz crystal microbalance biodetector based on cellulose nanofibrils (CNFs) for glycine


The performance of a quartz crystal microbalance (QCM) used as a sensor/detector relies on the performance and quality of the film coated onto the quartz crystal sensor. This study focuses on the sensor coating preparation for the detection of glycine. Cellulose nanofibrils (CNFs), natural polymers, were coated on a quartz crystal (QC) surface by a spin-coating method. The prepared CNF-coated QC was characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), cyclic voltammetry (CV), Fourier transform infrared spectrophotometry-attenuated total reflectance (FTIR-ATR), Raman spectroscopy, and water contact angle (WCA). The stable and fully covered QCs without further modification were then employed for aqueous glycine detection. Detection with a wide concentration range (3–1000 μg/mL) of glycine was studied. The resonance frequency shifts obtained from the samples during each step of the measurement are presented and discussed. The data show a linear range of detection (R2 = 0.9945) for 6–500 μg/mL of glycine and a limit of detection (LOD) of 8 μg/mL. This study indicates that the CNF-coated QCM has a potential application as a biodetector for glycine detection.

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We acknowledge the Iran National Science Foundation (INSF) for financial supports. The INSF supported this work with Grant Number 940011.

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Hosseini, M.S., Iraji zad, A., Vossoughi, M. et al. Development of a quartz crystal microbalance biodetector based on cellulose nanofibrils (CNFs) for glycine. J Mater Sci: Mater Electron 31, 17451–17460 (2020).

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