Skip to main content
SpringerLink
Log in

In2S3 nanosheet arrays grown on the 3D graphene for sensitive detection of epinephrine in the presence of uric acid

  • Published:
Journal of Materials Science: Materials in Electronics Aims and scope Submit manuscript

Abstract

In this paper, a simple and efficient electrochemical sensor based on indium sulfide nanosheet arrays (In2S3 NSAs) grown on 3D graphene (3D Gr) has been developed. 3D Gr was obtained by chemical vapor deposition (CVD) and In2S3 NSAs were prepared by a hydrothermal method. The composite (In2S3 NSAs-3D Gr) has a large accommodation space to contact with biological molecules. The current generated by the redox reaction of epinephrine (EP) on the surface of the In2S3 NSAs-3D Gr becomes an important indicator of the sensor value. The sensitivity of the sensor for the detection of EP in the range of 0–60 µm is 2.46 µA µM− 1 with a detection limit of 0.12 µM (S/N = 3). Meanwhile, the novel sensor has a good stability and selectivity. It also has potential for real detection of EP in human serum.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. H.F. Brown, D. Difrancesco, S.J. Noble, How does adrenaline accelerate the heart? Nature 280(5719), 235–236 (1979)

    Article  CAS  Google Scholar 

  2. P. Narchi, J.X. Mazoit, S. Cohen et al., Heart rate response to an I.V. Test dose of adrenaline and lignocaine with and without atropine pretreatment. Br. J. Anaesth. 66(5), 583–586 (1991)

    Article  CAS  Google Scholar 

  3. M.C. Cruz, R.S. Carvalho, P.M. Daniel et al., A rash decision. The hazards of the wrongful use of adrenaline. Rom J Anaesth Intensive Care 24(2), 163–166 (2017)

    Google Scholar 

  4. J. Droste, N. Narayan, Anaphylaxis, Lack of hospital doctors' knowledge of adrenaline (epinephrine) administration in adults could endanger patients' safety. European Annals of Allergy & Clinical Immunology 44(3), 122–127 (2012)

    CAS  Google Scholar 

  5. G.A. Tığ, Development of electrochemical sensor for detection of ascorbic acid, dopamine, uric acid and l-tryptophan based on Ag nanoparticles and poly (l-arginine)-graphene oxide composite. J. Electroanal. Chem. 807(15), 19–28 (2017)

    Article  Google Scholar 

  6. Z. Jing, Z. Yan, G. Man-Dong, An electrochemical sensor for determination of adrenaline based on AuNPs-LDHs film. Journal of Analytical Science 33(3), 357–361 (2017)

    Article  Google Scholar 

  7. S.S. Shankar, R.M. Shereema, R.B. Rakhi, Electrochemical determination of adrenaline using MXene/Graphite composite paste electrodes. ACS Applied Materials Interfaces 10(50), 43343–43351 (2018)

    Article  CAS  Google Scholar 

  8. G. Maduraiveeran, M. Sasidharan, V. Ganesan, Electrochemical sensor and biosensor platforms based on advanced nanomaterials for biological and biomedical applications. Biosens Bioelectron 103(30), 113–129 (2018)

    Article  CAS  Google Scholar 

  9. M. Wang, L. Yan, W. Lei et al., A label-free fluorescence nanosensor for the determination of adrenaline based on graphene quantum dots. Anal. Methods 9(30), 4434–4438 (2017)

    Article  CAS  Google Scholar 

  10. W. Hsin-Pin, C. Tian-Lu, T. Wei-Lung, Phosphate-modified TiO2 nanoparticles for selective detection of dopamine, levodopa, adrenaline, and catechol based on fluorescence quenching. Langmuir the Acs Journal of Surfaces & Colloids 23(14), 7880–7885 (2007)

    Article  Google Scholar 

  11. A. Baran, L. Fox-Machado, Detection of adrenaline on poly(3-aminobenzylamine) ultrathin film by electrochemical-surface plasmon resonance spectroscopy. Langmuir Acs J. Surf. Colloids 26(23), 18476–18482 (2010)

    Article  Google Scholar 

  12. KAMBAS, Near band-edge optical investigation of α-In2S3 and α-In2S3 – xsex mixed crystals. Physica B Condensed Matter 160(2), 103–107 (1989)

    Article  CAS  Google Scholar 

  13. T. Sall, B.M. Soucase, M. Mollar et al., Chemical spray pyrolysis of β-In2S3 thin films deposited at different temperatures. J. Phys. Chem. Solids 76(76), 100–104 (2015)

    Article  CAS  Google Scholar 

  14. E. Ghorbani, K. Albe, Intrinsic point defects in β-In2S3 studied by means of hybrid density-functional theory. J. Appl. Phys. 123(10), 103–107 (2018)

    Article  Google Scholar 

  15. S. Wang, B.Y. Guan, Y. Lu et al., Formation of hierarchical In2S3-CdIn2S4 heterostructured nanotubes for efficient and stable visible light CO2 reduction. J. Am. Chem. Soc. 139(48), 17305–17308 (2017)

    Article  CAS  Google Scholar 

  16. K. Jeehwan, H. Homare, T.K. Todorov et al., High efficiency Cu2ZnSn (S,Se) 4 solar cells by applying a double In2S3/CdS emitter. Cheminform 46(5), 7427–7431 (2015)

    Google Scholar 

  17. F. Yu, W. Zhao, S. Liu, A straightforward chemical approach for excellent In2S3 electron transport layer for high-efficiency perovskite solar cells. RSC Adv. 9(2), 884–890 (2019)

    Article  CAS  Google Scholar 

  18. H. Cansizoglu, M.F. Cansizoglu, F. Watanabe et al., Enhanced photocurrent and dynamic response in vertically aligned In2S3/Ag core/shell nanorod array photoconductive devices. ACS Appl. Mater. Interfaces 6(11), 8673–8682 (2014)

    Article  CAS  Google Scholar 

  19. H. Cansizoglu, M.F. Cansizoglu, T. Karabacak, Effect of shell coating techniques on dynamic response of photoconductive core/shell nanorod arrays. Adv. Mater. Interfaces 2(16), 1500275 (2016)

    Article  Google Scholar 

  20. C. Wang, C. Mu, J. Xiang et al., Microwave synthesized In2S3@CNTs with excellent properties in lithium-ion battery and electromagnetic wave absorption. Chin. J. Chem. 36(2), 157–161 (2018)

    Article  Google Scholar 

  21. W. Sheng, S. Ye, M. Dou et al., Constructing 1D hierarchical heterostructures of MoS2 /In2S3 nanosheets on CdS nanorod arrays for enhanced photoelectrocatalytic H2 evolution. Appl. Surf. Sci. 436(1), 613–623 (2018)

    Article  CAS  Google Scholar 

  22. Z. Yanwu, M. Shanthi, C. Weiwei et al., Graphene and graphene oxide: synthesis, properties, and applications. Cheminform 22(35), 3906–3924 (2010)

    Google Scholar 

  23. F. Mori, M. Kubouchi, Y. Arao, Effect of graphite structures on the productivity and quality of few-layer graphene in liquid-phase exfoliation. J. Mater. Sci. 53(18), 12807–12815 (2018)

    Article  CAS  Google Scholar 

  24. B.H. Min, D.W. Kim, K.H. Kim et al., Bulk scale growth of CVD graphene on Ni nanowire foams for a highly dense and elastic 3D conducting electrode. Carbon 80(1), 446–452 (2014)

    Article  CAS  Google Scholar 

  25. H.Y. Yue, H. Zhang, S. Huang et al., Synthesis of ZnO nanowire arrays/3D graphene foam and application for determination of levodopa in the presence of uric acid. Biosens. Bioelectron. 89(15), 592–597 (2017)

    Article  CAS  Google Scholar 

  26. L. Stobinski, B. Lesiak, A. Malolepszy et al., Graphene oxide and reduced graphene oxide studied by the XRD, TEM and electron spectroscopy methods. J. Electron Spectrosc. Relat. Phenom. 195(15), 145–154 (2014)

    Article  CAS  Google Scholar 

  27. L. Hua, L. Ning, H. Zhang et al., A simple and convenient fluorescent strategy for the highly sensitive detection of dopamine and ascorbic acid based on graphene quantum dots. Talanta 189(1), 190–195 (2018)

    Google Scholar 

  28. D. Molinnus, G. Hardt, L. Käver et al., Chip-based biosensor for the detection of low adrenaline concentrations to support adrenal venous sampling. Sens. Actuators B Chem. 272(1), 21–27 (2018)

    Article  CAS  Google Scholar 

  29. M.D. Tezerjani, A. Benvidi, A.D. Firouzabadi et al., Epinephrine electrochemical sensor based on a carbon paste electrode modified with hydroquinone derivative and graphene oxide nano-sheets: Simultaneous determination of epinephrine, acetaminophen and dopamine. Measurement 101(4), 183–189 (2017)

    Article  Google Scholar 

  30. M.R. Akhgar, H. Beitollahi, M. Salari et al., Fabrication of a sensor for simultaneous determination of norepinephrine, acetaminophen and tryptophan using a modified carbon nanotube paste electrode. Anal. Methods 4(1), 259–264 (2012)

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work is supported by the fundamental research foundation for University of Heilongjiang province (LGYC2018JQ012) and the foundation for selected overseas Chinese Scholar, Ministry of personnel of Heilongjiang province (2018383).

Author information

Authors and Affiliations

  1. School of Materials Science and Engineering, Harbin University of Science and Technology, Harbin, 150040, People’s Republic of China

    Xinrui Guo, Hongyan Yue, Xin Gao, Yingyi Ma, Hongtao Chen, Pengfei Wu, Teng Zhang & Zengze Wang

  2. Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, People’s Republic of China

    Shuo Huang

Authors
  1. Xinrui Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hongyan Yue
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shuo Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xin Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yingyi Ma
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hongtao Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Pengfei Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Teng Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Zengze Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hongyan Yue.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Electronic supplementary material 1 (DOCX 5857 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Guo, X., Yue, H., Huang, S. et al. In2S3 nanosheet arrays grown on the 3D graphene for sensitive detection of epinephrine in the presence of uric acid. J Mater Sci: Mater Electron 31, 3549–3556 (2020). https://doi.org/10.1007/s10854-020-02903-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10854-020-02903-z

Search

Navigation