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AuNP-composited multilayers with pH-regulated near-infrared photothermal effect for intelligent and synergistic antibacterial performance

  • Polymers & biopolymers
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Abstract

Herein, materials with pH-regulated near-infrared (NIR) photothermal effect are utilized to realize the efficient, safe, and synergistic antibacterial treatment. Polymeric multilayers were prepared through layer-by-layer assembly and ultraviolet (UV) crosslinking, and the key factors affecting the surface charge and isoelectric point (IEP) of the multilayers were discussed. When the pH-responsive multilayers were obtained, gold nanoparticles (AuNPs) having photothermal effect were further assembled into them. The pH responsibility, photothermal effect and antibacterial performance of the multilayers were further studied. The AuNP-composited multilayers can be heated up to 60 °C in 5 min under NIR irradiation, showing a good photothermal property. The multilayers swell and become negatively charged in pH 7.4, whereas they shrink and become positively charged in pH 5.0. Meanwhile, due to the volume shrinkage of multilayers and thereby the aggregation of AuNPs, the photothermal effect is enhanced. Under the synergism effect of pH-regulated photothermal effect and cationic polymer, the bacteria are killed by the multilayer efficiently under NIR and acidic conditions. This study provided a new idea and method for adaptive and intelligent antibacterial treatment.

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Acknowledgements

The study was supported by Zhejiang Province Welfare Technology Research Project, China (Grant No. LGF20H140007) and Young Talents Project of Zhejiang Provincial Health Department, China (Grant No. 2019RC151) and Zhejiang Provincial Key Research and Development Program (2022C01174).

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  1. Dan Yu and Bingjie Xu have contributed equally to this work.

Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China

    Dan Yu

  2. MOE Key Laboratory of Advanced Textile Materials & Manufacturing Technology, Zhejiang Sci-Tech University, Hangzhou, 310018, China

    Bingjie Xu, Xiansheng Zhang, Dongming Qi & Jindan Wu

  3. Key Laboratory of Green Cleaning Technology &, Detergent of Zhejiang Province, Lishui, 323000, China

    Guanshi Chen, Yan Quan, Dongming Qi & Jindan Wu

  4. NICE Group Co. Ltd, Lishui, 323000, China

    Guanshi Chen & Yan Quan

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  1. Dan Yu
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Yu, D., Xu, B., Chen, G. et al. AuNP-composited multilayers with pH-regulated near-infrared photothermal effect for intelligent and synergistic antibacterial performance. J Mater Sci 57, 15171–15182 (2022). https://doi.org/10.1007/s10853-022-07592-z

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