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Citicoline–liposome/polyurethane composite scaffolds regulate the inflammatory response of microglia to promote nerve regeneration

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Abstract

Regulating the immune microenvironment around the central neurons is a difficult problem. To address this critical matter, drug-loading scaffolds are promising ways of releasing drugs directly to the surrounding cells and ignoring the influence of blood–brain barrier and blood–medullary barrier. Microglia are fundamental innate immune sentinels in the central nervous system, usually activated during neuroinflammation. Citicoline (CDPC), a neuroprotective agent on secondary injuries, is used in clinical treatment of central nervous system diseases. To overcome low efficiency of CDPC uptake and improve immune microenvironment of CDPC in central nervous system (CNS), in this work, double local drug delivery systems, hybrid CDPC–liposome and CDPC blending directly waterborne polyurethane scaffolds, were prepared. It shows that CDPC–liposome composite scaffolds are more conducive to inhibit the inflammatory response of microglia and promote axon elongation, which presents a certain prospect in the field of nerve repair.

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Acknowledgments

This work was financially supported by the National Natural Science Foundation of China Key Program Grants 51733005, 51873122 and 52003177. We are also grateful to Doctor Chenghui Li (Analytical & Center, Sichuan University) for her help in taking laser scanning confocal images.

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Authors and Affiliations

  1. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Med-X Center of Materials, Sichuan University, Chengdu, 610065, China

    Jingjing Lin, Xingying Song, Hang Yin, Nijia Song, Yanchao Wang, Zhen Li, Feng Luo, Hong Tan & Jiehua Li

  2. Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, 610000, Sichuan, China

    Yanchao Wang

  3. College of Chemistry and Materials Science, Sichuan Normal University, Chengdu, 610068, China

    Nijia Song

  4. Laboratory Animal Center of Sichuan University, Chengdu, 610041, China

    Xueling He

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  1. Jingjing Lin
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Lin, J., Song, X., Yin, H. et al. Citicoline–liposome/polyurethane composite scaffolds regulate the inflammatory response of microglia to promote nerve regeneration. J Mater Sci 57, 2073–2088 (2022). https://doi.org/10.1007/s10853-021-06628-0

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