Gd–chelate magnetic resonance imaging (MRI) contrast agents used in conventional clinical medicine still have some shortcomings, such as their low relaxation rates and poor imaging sensitivity. In this work, a Gd–chelate (Gd–DTPA), with a comparison made to the commercial contrast agent Magnevist was loaded into a zeolitic imidazolate framework (ZIF-8) to construct the efficient T1 MRI contrast agent Gd–DTPA@ZIF-8. At 0.5 T, the longitudinal relaxivity value (r1) of Gd–DTPA@ZIF-8 reaches 29.60 mM−1 s−1, which is about 6 times higher than that of Gd–DTPA. In terms of the retention of Gd–DTPA in ZIF-8, no obvious Gd3+ ions are released in water and complete culture solution over a long time period. Haemolysis and cytotoxicity experiments revealed that Gd–DTPA@ZIF-8 has good biocompatibility. In addition, the in vivo MRI results prove that Gd–DTPA@ZIF-8 can significantly enhance the T1-weighted MRI contrast effect of the tumour site. These advantages make Gd–DTPA@ZIF-8 a potential candidate for biomedical applications.
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This work was partially supported by National Natural Science Foundation of China (Nos. 21601124, 21671135 and 21701111), Shanghai Sailing Programme (17YF1413700), Ministry of Education of China (PCSIRT_IRT_16R49), and International Joint Laboratory on Resource Chemistry (IJLRC).
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Zhou, W., Shen, J., Lin, J. et al. Zeolitic imidazolate framework nanoparticles loaded with gadolinium chelate as efficient T1 MRI contrast agent. J Mater Sci 56, 7386–7396 (2021). https://doi.org/10.1007/s10853-020-05647-7