Skip to main content

Advertisement

SpringerLink
Log in

Mechanical, physical–chemical and biological properties of the new Ti–30Nb–13Ta–5Zr alloy

  • Materials for life sciences
  • Published:
Journal of Materials Science Aims and scope Submit manuscript

Abstract

A technology was developed to obtain homogeneous Ti–30Nb–13Ta–5Zr alloy. The alloy was shown to consist of a pure β-crystalline phase and possesses requisite mechanical properties. The alloy surface exhibits micro- and nanoscale structures. In terms of the ability to generate reactive oxygen species and long-lived reactive protein species, Ti–30Nb–13Ta–5Zr alloy is more favorable compared to nitinol. A high mitotic index (2%) and low content of non-viable cells (< 5%) were observed when growing cell cultures on Ti–30Nb–13Ta–5Zr alloy scaffolds. Cells readily attach and spread over the alloy surface. The biocompatibility of Ti–30Nb–13Ta–5Zr was confirmed by the results of implantation of the alloy in the form of plates or looped wire. Surface morphology of the samples showed no significant changes after biological testing. It can be assumed that Ti–30Nb–13Ta–5Zr is a material potentially suitable for use in medicine.

Graphical abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7

Similar content being viewed by others

References

  1. Gluck T (2011) Report on the positive results obtained by the modern surgical experiment regarding the suture and replacement of defects of superior tissue, as well as the utilization of re-absorbable and living tamponade in surgery. Clin Orthop Relat Res 469:1528–1535

    Google Scholar 

  2. Katz D, O’Toole G, Cogswell L, Sauzieres P, Valenti P (2007) A history of the reverse shoulder prosthesis. Int J Shoulder Surg 1:108–113

    Google Scholar 

  3. Ghoul WE, Chidiac JJ (2012) Prosthetic requirements for immediate implant loading: a review. J Prosthodont 21:141–154

    Google Scholar 

  4. Condon R, Beder O (1964) A study of titanium implants in a corrosion-producing environment. Surgery 55:714–717

    CAS  Google Scholar 

  5. Niinomi M (2018) Recent progress in research and development of metallic structural biomaterials with mainly focusing on mechanical biocompatibility. Mater Trans 59(1):11–13

    Google Scholar 

  6. Trino LD, Bronze-Uhle ES, Ramachandran A, Lisboa-Filho PN, Mathew MT, George A (2018) Titanium surface bio-functionalization using osteogenic peptides: surface chemistry, biocompatibility, corrosion and tribocorrosion aspects. J Mech Beh Biomed Mater 81:26–38

    CAS  Google Scholar 

  7. Duerig T, Pelton A, Stöckel D (1999) An overview of nitinol medical applications. Mater Sci Eng, A 273–275:149–160

    Google Scholar 

  8. Sanghvi N, Crasta F, Kottur VKN (2019) Review of application of nitinol in the manufacture of bone staples. In: Vasudevan H, Kottur V, Raina A (eds) Proceedings of international conference on intelligent manufacturing and automation. Lecture notes in mechanical engineering. Springer, Singapore

  9. Saito M, Arakaki R, Yamada A, Tsunematsu T, Kudo Y, Ishimaru N (2016) Molecular mechanisms of nickel allergy. Int J Mol Sci 17:E202

    Google Scholar 

  10. Ranganathan S (2003) Alloyed pleasures: multimetallic cocktails. Curr Sci 85:1404–1406

    Google Scholar 

  11. Shimojo N, Kondo C, Yamashita K, Hoshino T, Hayakawa T (2007) Cytotoxicity analysis of a novel titanium alloy in vitro: adhesion, spreading, and proliferation of human gingival fibroblasts. Biomed Mater Eng 17(2):127–135

    CAS  Google Scholar 

  12. Choi K, Kim M, Zhu J, Zhang F, Song Y, Yi S, Park JS (2018) Collapse of lamellar structure and stability with the addition of Misch metal (Mm) to the cast Ti–Al–Mo–Nb–(Mm) alloys. J Mater Sci 53:12504–12511. https://doi.org/10.1007/s10853-018-2439-5

    Article  CAS  Google Scholar 

  13. Xu R, Liu B, Yan Z, Chen F, Guo W, Liu Y (2019) Low-cost and high-strength powder metallurgy Ti–Al–Mo–Fe alloy and its application. J Mater Sci 54:12049–12060. https://doi.org/10.1007/s10853-019-03734-y

    Article  CAS  Google Scholar 

  14. Dai J, Xia J, Chai L, Murty KL, Guo N, Daymond MR (2020) Correlation of microstructural, textural characteristics and hardness of Ti–6Al–4 V sheet β-cooled at different rates. J Mater Sci 55:8346–8362. https://doi.org/10.1007/s10853-020-04603-9.pdf

    Article  CAS  Google Scholar 

  15. Biesiekierski A, Wang J, Gepreel M, Wen C (2012) A new look at biomedical Ti-based shape memory alloys. Acta Biomater 8(5):1661–1669

    CAS  Google Scholar 

  16. Ozan S, Lin J, Li Y, Wen C (2017) New Ti–Ta–Zr–Nb alloys with ultrahigh strength for potential orthopedic implant applications. J Mech Behav Biomed Mater 75:119–127

    CAS  Google Scholar 

  17. Preisler D, Janeček M, Harcuba P, Džugan J, Halmešová K, Málek J, Veverková A, Stráský J (2019) The effect of hot working on the mechanical properties of high strength biomedical Ti–Nb–Ta–Zr–O alloy. Materials (Basel) 12(24):E4233

    Google Scholar 

  18. Eisenbarth E, Velten D, Muller M, Thull R, Breme J (2004) Biocompatibility of b-stabilizing elements of titanium alloys. Biomaterials 25(26):5705–5713

    CAS  Google Scholar 

  19. Murray JL (1981) The Ta − Ti (Tantalum–Titanium) system. Bull Alloy Phase Diagr 2:62–66

    Google Scholar 

  20. Sergienko KV, Sevost’yanov MA, Konushkin SV, Nasakina EO, Baikin AS, Shatova LA, Kolmakov AG (2018) Investigation of static properties of medical alloys Ti–(20–30)Nb–(10–13)Ta–5Zr. IOP Conf Ser Mater Sci Eng 347:012049

    Google Scholar 

  21. Magdalen HC, Baghi AD, Ghomashchi R, Xiao W, Oskouei RH (2019) Effect of niobium content on the microstructure and Young’s modulus of Ti–xNb–7Zr alloys for medical implants. J Biomed Mater 99:78–85

    Google Scholar 

  22. Fanton L, Cremasco A, Mello MG, Caram R (2019) Anodization growth of TiO2 nanotubes on Ti–35Nb–7Zr–5Ta alloy: effects of anodization time, strain hardening, and crystallographic texture. J Mater Sci 54:13724–13739. https://doi.org/10.1007/s10853-019-03870-5

    Article  CAS  Google Scholar 

  23. Soro N, Attar H, Brodie E, Veidt M, Molotnikov A, Dargusch MS (2019) Evaluation of the mechanical compatibility of additively manufactured porous Ti–25Ta alloy for load-bearing implant applications. J Mech Behav Biomed Mater 97:149–158

    CAS  Google Scholar 

  24. Li Z, Zheng B, Wang Y, Topping T, Zhou Y, Valiev RZ, Shan A, Lavernia EJ (2014) Ultrafine-grained Ti–Nb–Ta–Zr alloy produced by ECAP at room temperature. J Mater Sci 49:6656–6666. https://doi.org/10.1007/s10853-014-8337-6

    Article  CAS  Google Scholar 

  25. Sharapov MG, Novoselov VI, Penkov NV, Fesenko EE, Vedunova MV, Bruskov VI, Gudkov SV (2019) Protective and adaptogenic role of peroxiredoxin 2 (Prx2) in neutralization of oxidative stress induced by ionizing radiation. Free Radic Biol Med 134:76–86

    CAS  Google Scholar 

  26. Chernikov AV, Gudkov SV, Shtarkman IN, Bruskov VI (2007) Oxygen effect in heat-mediated damage to DNA. Biofizika 52(2):244–251

    CAS  Google Scholar 

  27. Shtarkman IN, Gudkov SV, Chernikov AV, Bruskov VI (2008) Effect of amino acids on X-ray-induced hydrogen peroxide and hydroxyl radical formation in water and 8-oxoguanine in DNA. Biochemistry (Mosc) 73(4):470–478

    CAS  Google Scholar 

  28. Gudkov SV, Guryev EL, Gapeyev AB, Sharapov MG, Bunkin NF, Shkirin AV, Zabelina TS, Glinushkin AP, Sevost’yanov MA, Belosludtsev KN, Chernikov AV, Bruskov VI, Zvyagin AV (2019) Unmodified hydrated C(60) fullerene molecules exhibit antioxidant properties, prevent damage to DNA and proteins induced by reactive oxygen species and protect mice against injuries caused by radiation-induced oxidative stress. Nanomedicine 15(1):37–46

    CAS  Google Scholar 

  29. Chernov AS, Reshetnikov DA, Kovalitskaya YuA, Manokhin AA, Gudkov SV (2018) Influence of wideband visible light with an padding red component on the functional state of mice embryos and embryonic stem cells. J Photochem Photobiol, B 188:77–86

    CAS  Google Scholar 

  30. Sevost’yanov MA, Nasakina EO, Baikin AS, Sergienko KV, Konushkin SV, Kaplan MA, Seregin AV, Leonov AV, Kozlov VA, Shkirin AV, Bunkin NF, Kolmakov AG, Simakov SV, Gudkov SV (2018) Biocompatibility of new materials based on nano-structured nitinol with titanium and tantalum composite surface layers: experimental analysis in vitro and in vivo. J Mater Sci Mater Med 29(3):33

    Google Scholar 

  31. Kaplan MA, Sergienko KV, Kolmakova AA, Konushkin SV, Baikin AS, Kolmakov AG, Sevostyanov MA, Kulikov AV, Ivanov VE, Belosludtsev KN, Antipov SS, Volkov MY, Shusharina NN, Karaduleva EV, Kozlov VA, Simakin AV, Gudkov SV (2020) Development of a biocompatible PLGA polymers capable to release thrombolytic enzyme prourokinase. J Biomater Sci Polym Ed. https://doi.org/10.1080/09205063.2020.1760699

    Article  Google Scholar 

  32. Leventhal GS (1951) Titanium, a metal for surgery. J Bone Jt Surg Am 33:473–474

    Google Scholar 

  33. García-Martínez E, Miguel V, Martínez-Martínez A, Manjabacas MC, Coello J (2019) Sustainable lubrication methods for the machining of titanium alloys: an overview. Materials (Basel) 12(23):E3852

    Google Scholar 

  34. Barras CD, Myers KA (2000) Nitinol: its use in vascular surgery and other applications. Eur J Vasc Endovasc Surg 19(6):564–569

    CAS  Google Scholar 

  35. Shabalovskaya SA (1996) On the nature of the biocompatibility and on medical applications of NiTi shape memory and superelastic alloys. Biomed Mater Eng 6(4):267–289

    CAS  Google Scholar 

  36. Di Gioacchino M, Ricciardi L, De Pità O, Minelli M, Patella V, Voltolini S, Di Rienzo V, Braga M, Ballone E, Mangifesta R, Schiavino D (2014) Nickel oral hyposensitization in patients with systemic nickel allergy syndrome. Ann Med 46(1):31–37

    Google Scholar 

  37. Cheng X, Liu S, Chen C, Chen W, Liu M, Li R, Zhang X, Zhou K (2019) Microstructure and mechanical properties of additive manufactured porous Ti–33Nb–4Sn scaffolds for orthopaedic applications. J Mater Sci Mater Med 30:91

    Google Scholar 

  38. Zhou YL, Niinomi M (2009) Ti–25Ta alloy with the best mechanical compatibility in Ti–Ta alloys for biomedical applications. Mater Sci Eng, C 29(3):1061–1065

    CAS  Google Scholar 

  39. Nasakina EO, Konushkin SV, Baskakova MI, Fedyuk IM, Sergienko KV, Baikin AS, Kaplan MA, Sevostyanov MA, Kolmakov AG (2018) The production of a thin wire of Ti–Nb–Ta–Zr shape memory alloy for medical devices. J Mater Sci Eng 7(2):430–436

    Google Scholar 

  40. Burton M (1950) Radiation chemistry. Ann Rev Phys Chem 1:113–132

    CAS  Google Scholar 

  41. Gudkov SV, Andreev SN, Barmina EV, Bunkin NF, Kartabaeva BB, Nesvat AP, Stepanov EV, Taranda NI, Khramov RN, Glinushkin AP (2017) Effect of visible light on biological objects: physiological and pathophysiological aspects. Phys Wave Phenom 25(3):207–213

    Google Scholar 

  42. Neyens E, Baeyens J (2003) A review of classic Fenton’s peroxidation as an advanced oxidation technique. J Hazard Mater 98(1–3):33–50

    CAS  Google Scholar 

  43. Gudkov SV, Chernikov AV, Bruskov VI (2016) Chemical and radiological toxicity of uranium compounds. Rus J Gen Chem 86(6):1531–1538

    CAS  Google Scholar 

  44. Boldinova EO, Wanrooij PH, Shilkin ES, Wanrooij S, Makarova AV (2017) DNA damage tolerance by eukaryotic DNA polymerase and primase PrimPol. Int J Mol Sci 18(7):E1584

    Google Scholar 

  45. Filev AD, Shmarina GV, Ershova ES, Veiko NN, Martynov AV, Borzikova MA, Poletkina AA, Dolgikh OA, Veiko VP, Bekker AA, Chirkov AV, Volynshchikov ZN, Deviataikina AS, Shashin DM, Puretskiy VK, Tabakov VJ, Izhevskaya VL, Kutsev SI, Kostyuk SV, Umriukhin PE (2019) Oxidized cell-free DNA role in the antioxidant defense mechanisms under stress. Oxid Med Cell Longev 2019:1245749

    CAS  Google Scholar 

  46. Bruskov VI, Malakhova LV, Masalimov ZK, Chernikov AV (2002) Heat-induced formation of reactive oxygen species and 8-oxoguanine, a biomarker of damage to DNA. Nucl Acids Res 30(6):1354–1363

    CAS  Google Scholar 

  47. Moldogazieva NT, Mokhosoev IM, Mel’nikova TI, Porozov YB, Terentiev AA (2019) Oxidative stress and advanced lipoxidation and glycation end products (ALEs and AGEs) in aging and age-related diseases. Oxid Med Cell Longev 2019:3085756

    Google Scholar 

  48. Fenton HJH (1894) Oxidation of tartaric acid in presence of iron. J Chem Soc Trans 65:899–911

    CAS  Google Scholar 

  49. Toyokuni S (1996) Iron-induced carcinogenesis: the role of redox regulation. Free Radic Biol Med 20(4):553–566

    CAS  Google Scholar 

  50. Bruskov VI, Karp OE, Garmash SA, Shtarkman IN, Chernikov AV, Gudkov SV (2012) Prolongation of oxidative stress by long-lived reactive protein species induced by X-ray radiation and their genotoxic action. Free Radic Res 46(10):1280–1290

    CAS  Google Scholar 

  51. Kasemo B (1983) Biocompatibility of titanium implants: surface science aspects. J Prosthet Dent 49(6):832–837

    CAS  Google Scholar 

  52. Johansson CB, Albrektsson T (1991) A removal torque and histomorphometric study of commercially pure niobium and titanium implants in rabbit bone. Clin Oral Implants Res 2(1):24–29

    CAS  Google Scholar 

  53. Wang Q, Zhang H, Li Q, Ye L, Gan H, Liu Y, Wang H, Wang Z (2015) Biocompatibility and osteogenic properties of porous tantalum. Exp Ther Med 9(3):780–786

    CAS  Google Scholar 

  54. Saldaña L, Méndez-Vilas A, Jiang L, Multigner M, González-Carrasco JL, Pérez-Prado MT, González-Martín ML, Munuera L, Vilaboa N (2007) In vitrobiocompatibility of an ultrafine grained zirconium. Biomaterials 28(30):4343–4354

    Google Scholar 

Download references

Acknowledgements

The authors would like to thank Dr. Alexey Berezhnov for helping with cell cultures and Prof. Alexander Kulikov for help with animal treatment. The authors are grateful to the Center for Collective Use of the GPI RAS for the equipment provided.

Author information

Authors and Affiliations

  1. A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow, Russia

    Mikhail A. Sevostyanov, Alexey G. Kolmakov, Konstantin V. Sergiyenko, Mikhail A. Kaplan & Alexander S. Baikin

  2. All-Russian Research Institute of Phytopatology, Bol’shie Vyazemy, Moscow Oblast, Russia

    Mikhail A. Sevostyanov

  3. Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russia

    Sergey V. Gudkov

Authors
  1. Mikhail A. Sevostyanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alexey G. Kolmakov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Konstantin V. Sergiyenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mikhail A. Kaplan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Alexander S. Baikin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sergey V. Gudkov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sergey V. Gudkov.

Ethics declarations

Conflict of interest

The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sevostyanov, M.A., Kolmakov, A.G., Sergiyenko, K.V. et al. Mechanical, physical–chemical and biological properties of the new Ti–30Nb–13Ta–5Zr alloy. J Mater Sci 55, 14516–14529 (2020). https://doi.org/10.1007/s10853-020-05020-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10853-020-05020-8

Search

Navigation