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Fabrication of a novel antibacterial TPU nanofiber membrane containing Cu-loaded zeolite and its antibacterial activity toward Escherichia coli

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Abstract

A novel antibacterial thermoplastic polyurethane (TPU) nanofiber membrane was fabricated by electrospinning with the aid of Cu-loaded NaX zeolite (CuX), which showed excellent and long-lasting antibacterial activity against Escherichia coli (E. coli). The crystalline structure, morphology and composition of the obtained NaX zeolite, CuX and CuX/TPU nanofiber membrane were analyzed by X-ray diffraction (XRD), scanning electron microscope (SEM) and X-ray fluorescence (XRF), respectively. The antibacterial activity of CuX/TPU nanofiber membrane against E. coli was investigated by inhibition zone method and plate-counting method, and it is indicated that the inactivation efficiency was increased from 58.40 to 99.85% with increasing the addition of CuX from 5 to 30% in 4 h. The result of kinetics study indicated that the disinfection process accorded with the pseudo-first-order model. The possible antibacterial mechanism was also proposed that the released Cu2+ by CuX in nanofiber membrane destroyed the cell wall and penetrated plasma membrane of E. coli. It is expected that this CuX/TPU nanofiber membrane with excellent antibacterial activity would be a promising candidate for biomedical applications.

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Acknowledgements

The authors gratefully acknowledge the financial support provided by the Young Elite Scientists Sponsorship Program by CAST (2017QNRC001), Yueqi Funding Scheme for Young Scholars (China university of Mining &Technology, Beijing), Beijing Excellent Talent Training Subsidy Program (2017000020124G089), Science and technology Project of Beijing Municipal Education Commission (KM201910012010), High Levels of Teachers’ Team Construction Special Funds of Beijing Institute of Fashion Technology (BIFTQG201807) and Talent introduction program of Beijing Institute of Fashion Technology (2017A-19).

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Authors and Affiliations

  1. School of Chemical and Environmental Engineering, China University of Mining and Technology (Beijing), Beijing, 100083, People’s Republic of China

    Jingjing Lei, Guangyuan Yao, Zhiming Sun, Caihong Yu & Shuilin Zheng

  2. Beijing Key Laboratory of Clothing Materials R&D and Assessment, Beijing Engineering Research Center of Textile Nanofiber, School of Materials, Design and Engineering, Beijing, 100029, People’s Republic of China

    Bin Wang

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  1. Jingjing Lei
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  2. Guangyuan Yao
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  3. Zhiming Sun
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  4. Bin Wang
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Correspondence to Zhiming Sun or Bin Wang.

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Lei, J., Yao, G., Sun, Z. et al. Fabrication of a novel antibacterial TPU nanofiber membrane containing Cu-loaded zeolite and its antibacterial activity toward Escherichia coli. J Mater Sci 54, 11682–11693 (2019). https://doi.org/10.1007/s10853-019-03727-x

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