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A doxorubicin and vincristine drug release system based on magnetic PLGA microspheres prepared by coaxial electrospray

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Abstract

In this study, we demonstrated a novel doxorubicin and vincristine-loaded PLGA magnetic microspheres prepared by coaxial electrospray, as a drug delivery system for osteosarcoma treatment. The results showed that microspheres had an minimum mean diameter of 0.32 ± 0.25 μm and exhibited a spherical shape. The particle size distribution changed obviously with the different dosing ways. The entrapment efficiency was found to be 65.72, 73.6 and 74.14% for different microspheres. In vitro degradation research showed that circular pores appeared gradually on the surface of particles with the increase in time, which accelerated the degradation of microspheres. CCK-8 test showed that the Fe3O4@PLGA microspheres without drug loading had almost no side effects, the cytotoxicity of Fe3O4@P/(V + D), Fe3O4@(P + D)/V and Fe3O4@(P + V)/D microspheres increased in turn, and Fe3O4@(P + V)/D microspheres with minimum particle size could significantly arrest the growth of osteosarcoma saos-2 cells. Therefore, the drug-loaded magnetic microspheres have good killing effect on osteosarcoma cell lines, which can be used as an ideal targeting treatment for postoperative adjuvant therapy of osteosarcoma.

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Acknowledgements

The work was supported by Jilin Province Health Project 2018 (3D517EB73428) and Key Project of Science and Technology Development Plan, Jilin Province of China (20170204042GX).

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Authors and Affiliations

  1. Alan G. MacDiarmid Laboratory, College of Chemistry, Jilin University, Changchun, 130012, People’s Republic of China

    Yajun Tang, He Zhao & Mei Zhang

  2. Norman Bethune First Hospital, Jilin University, Changchun, 130021, People’s Republic of China

    Jihang Yao, Zhenhua Zhu & Dahui Sun

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  1. Yajun Tang
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Tang, Y., Zhao, H., Yao, J. et al. A doxorubicin and vincristine drug release system based on magnetic PLGA microspheres prepared by coaxial electrospray. J Mater Sci 54, 9689–9706 (2019). https://doi.org/10.1007/s10853-019-03575-9

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