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Fabricated porous silk fibroin particles for pH-responsive drug delivery and targeting of tumor cells

Abstract

To improve the roles of tumor drug, porous silk fibroin particles have been designed as drug carriers. Doxorubicin (DOX) is encapsulated during the fabrication process of the silk fibroin particles to form DOX loaded silk fibroin particles (SFPs-DOX). Folic acid (FA) is covalently grafted to the surface of the silk fibroin particles (FA-SFPs-DOX) as a target group to the folate receptor of tumor cells. The experimental results showed that under the conditions of low pH, high ionic strength and high enzyme concentration, the release of loaded drugs in particles has stimulus response under various conditions. The synthesized silk fibroin particles have good biocompatibility. The specific binding of fibroin particles to folate receptors provides the particles to with target functions to the tumor cells. The job develops potential application of silk fibroin particles as smart drug carriers for the targeted therapy of tumor.

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Acknowledgements

The work is financially supported by the Program for National Natural Science Foundation of China (51372226), Zhejiang Provincial Natural Science Foundation of China (LY16E020013) and Zhejiang Top Priority Discipline of Textile Science and Engineering (2015KF23). SCK presently holds an ERA Chair Full Professor position at I3Bs—Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Portugal, supported by the European Union Framework Programme for Research and Innovation HORIZON 2020 under Grant Agreement No. 668983—FoReCaST.

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Correspondence to Yurong Cai.

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Sun, N., Lei, R., Xu, J. et al. Fabricated porous silk fibroin particles for pH-responsive drug delivery and targeting of tumor cells. J Mater Sci 54, 3319–3330 (2019). https://doi.org/10.1007/s10853-018-3022-9

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  • DOI: https://doi.org/10.1007/s10853-018-3022-9

Keywords

  • Folic Acid (FA)
  • Folate Receptor
  • Drug Carriers
  • Cumulative Release Rate
  • Silk Fibroin Protein