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Preparation and photothermal therapy of hyaluronic acid–conjugated Au nanoparticle-coated poly (glycidyl methacrylate) nanocomposites

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Abstract

Nanocomposites are fabricated with poly (glycidyl methacrylate) (PGMA) microspheres, Au nanoparticles and hyaluronic acid (HA) for accurate photothermal therapy. PGMA microspheres are synthesized by emulsifier-free emulsion polymerization followed by amination. The adsorption of gold seeds is successfully achieved through chelation. PGMA@Au-4 nanocomposites (abbreviated as PGMA@Au) are obtained after gold seed growth. The temperature of the 0.3 mg mL−1 PGMA@Au dispersion increases by 10.6 °C when irradiated with a near-infrared (NIR) laser for 5 min. In order to reduce side effects in normal cells and achieve a specific targeting property for cancer cells, HA is further conjugated on the surface of PGMA@Au (denoted as PGMA@Au–HA). The PGMA@Au–HA nanocomposites perform highly selective targeting toward cancer cells and have good photothermal properties, leading to threefold therapeutic efficacy against cancer cells in comparison with normal cells. These results indicate that the PGMA@Au–HA construct could be a promising platform for cancer therapy.

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Acknowledgements

The authors are grateful for the financial support sponsored by the Science and Technology Project of Shenzhen (No. JCYJ20170306154725569), the National Natural Science Foundation of China (No. 81601606), the Seed Foundation of Innovation and Creation for Graduate Students in Northwestern Polytechnical University (No. ZZ2018183) and the National Undergraduate Innovation and Entrepreneurship Training Program (No. 201710699252).

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Authors and Affiliations

  1. The Key Laboratory of Space Applied Physics and Chemistry, School of Science, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China

    Hepeng Zhang, Yonggang Zhang, Chen Wu, Baoliang Zhang & Qiuyu Zhang

  2. School of Chemical Engineering and Technology, Institute of Polymer Science in Chemical Engineering, Xi’an Jiao Tong University, Xi’an, 710049, People’s Republic of China

    Ronghua Jin & Xin Chen

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  1. Hepeng Zhang
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  2. Yonggang Zhang
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  4. Chen Wu
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Correspondence to Hepeng Zhang or Xin Chen.

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Zhang, H., Zhang, Y., Jin, R. et al. Preparation and photothermal therapy of hyaluronic acid–conjugated Au nanoparticle-coated poly (glycidyl methacrylate) nanocomposites. J Mater Sci 53, 16252–16262 (2018). https://doi.org/10.1007/s10853-018-2773-7

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