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Journal of Materials Science

, Volume 53, Issue 18, pp 12692–12703 | Cite as

Novel amphiphilic heparin-pluronic P123 copolymers exhibiting a great potential for Cisplatin delivery

  • Ngoc The Nguyen
  • Thi Hiep Nguyen
  • Minh Thanh Vu
  • Van Thu Le
  • Xuan Anh Nguyen
  • Tram Chau Nguyen
  • Thi Bich Tram Nguyen
Biomaterials
  • 244 Downloads

Abstract

In the study, we introduced a series of amphiphilic pluronic P123-conjugated heparin (hep-P123) copolymers which were characterized for drug delivery. In regard to the research, various grafted hep-P123 copolymers investigated its potential in the delivery of hydrophobic Cisplatin (Cis) anticancer drugs and its aquated species (CisOH) via hydrophobic interaction and complex formation, respectively. Hep-P123 was obtained via conjugation of the partially NPC-activated pluronic P123 (NPC-P123-OH) onto the aminated heparin (hep-DAB). The obtained copolymers were characterized by 1H-NMR and thermal gravimetric analysis. The effect of P123 conjugation degree on size distribution of nanocarriers was evaluated by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The results showed that size distribution of hep-P123 nanogels range from 62.2 ± 19.4 nm to 114.5 ± 21.7 nm by TEM and 94.4–182.4 nm by DLS. Complex formation of the CisOH was clarified by FT-IR. Loading efficiency of Cis/CisOH was evaluated by inductively coupled plasma atomic emission spectroscopy that indicated a relation between the conjugated degree of hep-P123 and amount of loaded drugs. In addition, hep-P123 exhibited a higher CisOH binding efficiency via complexation as compared to the loaded Cis by hydrophobic interaction. The CisOH and hep-P123 nanocomplex performed a high activity against NCI-H460 cancer cell growth. The obtained results offered an appropriate selection of the hep-P123 platform for dual drugs delivery of CisOH and other hydrophobic anticancer drugs which could utilize both hydrophobic interaction and complex formation.

Notes

Acknowledgements

This work was financially supported by Vietnam National Foundation for Science and Technology Development (NAFOSTED) [grant number 106-YS.99-2014.33]. This work was also supported by Thu Dau Mot University and Tra Vinh University. Authors are deeply grateful to Professor Ngoc Quyen Tran for all his support.

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Pharmacy and MedicineTraVinh UniversityTravinh CityVietnam
  2. 2.Graduate School of Science and TechnologyVietnam Academy of Science and TechnologyHochiminh CityVietnam
  3. 3.Biomedical Engineering DepartmentInternational University, National Universities in HochiminhHochiminh CityVietnam
  4. 4.Institute of Chemistry and MaterialsHanoiVietnam
  5. 5.Institute of Applied Materials ScienceVietnam Academy of Science and TechnologyHochiminh CityVietnam
  6. 6.Department of Chemical EngineeringIndustrial University of Hochiminh CityHochiminh CityVietnam
  7. 7.Department of Natural ScienceThu Dau Mot UniversityThu Dau MotVietnam

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