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Zeolitic imidazolate metal organic framework-8 as an efficient pH-controlled delivery vehicle for zinc phthalocyanine in photodynamic therapy

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Abstract

To improve the aqueous solubility and cancer targeting of the photosensitizers in photodynamic therapy (PDT), we encapsulated the photosensitizer in a biocompatibility and pH-sensitive drug delivery system, zeolitic imidazolate frameworks-8 (ZIF-8) nanospheres. Powder X-ray diffraction and electron microscopy show that our nanospheres are uniform and single-crystalline particles. Owing to the cleavage of zinc–ligand coordination bonds, more ZnPc–COOH were released much faster in the mild acidic conditions (pH 5.0 and 6.0) in comparison with physiological environment (pH 7.4). By incorporating ZnPc–COOH in ZIF-8, our nanospheres exhibited high singlet oxygen quantum yield and intracellular ROS generation. Cell viability experiments toward HepG2 cells demonstrated the low toxicity of ZIF-8 and the good anticancer efficacy of the nanospheres with low IC50 values (4.2–4.9 μg/mL) under light illumination (670 nm, 1.5 J/cm2). Collectively, these results suggested that our nanospheres are the promising pH-responsive drug delivery systems for PDT.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 81703345), the Major Project of the State Ministry of Science and Technology of China (No. 2011ZX09101-001-04), the Independent Research Project of State Key Laboratory of Photocatalysis on Energy and Environment (No. 2014A04), the Natural Science Foundation of Fujian Province (No. 2016J05034) and Foundation of Fujian Educational Committee (No. JA15084).

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Authors and Affiliations

  1. National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, College of Chemistry, Fuzhou University, Fuzhou, 350116, Fujian, China

    Mei-Ru Song, Dong-Yao Li, Fu-Yu Nian, Jin-Ping Xue & Juan-Juan Chen

  2. Fujian Engineering Research Center for Drug and Diagnoses-Treat of Photodynamic Therapy, College of Chemistry, Fuzhou University, Fuzhou, 350116, Fujian, China

    Mei-Ru Song, Dong-Yao Li, Fu-Yu Nian, Jin-Ping Xue & Juan-Juan Chen

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  1. Mei-Ru Song
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Correspondence to Juan-Juan Chen.

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Song, MR., Li, DY., Nian, FY. et al. Zeolitic imidazolate metal organic framework-8 as an efficient pH-controlled delivery vehicle for zinc phthalocyanine in photodynamic therapy. J Mater Sci 53, 2351–2361 (2018). https://doi.org/10.1007/s10853-017-1716-z

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