Advertisement

Journal of Materials Science

, Volume 52, Issue 24, pp 13700–13710 | Cite as

Surface modification of a novel glass to optimise strength and deliverability of an injectable alginate composite

  • S. A. Brady
  • E. K. Fox
  • F. R. Laffir
  • B. Phelan
  • A. O’Hare
  • C. Lally
  • O. M. ClarkinEmail author
Biomaterials

Abstract

It is estimated that 1–6% of the adult population have an intracranial aneurysm. Aneurysm coiling is the current preferred treatment method; however, over 20% of coiled aneurysms recur. A novel glass–alginate composite hydrogel has been developed to treat aneurysms, which is designed to completely fill the aneurysm space and prevent aneurysm recurrence. This hydrogel is composed of a polymeric alginate, a novel bioactive glass and glucono-delta-lactone. This novel injectable hydrogel exhibits characteristics suitable for the treatment of cerebral aneurysms. However, poor hydrophilicity of the glass phase results in inhomogeneity and agglomerate formation within the composite, resulting in suboptimal deliverability and strength. This study examines the effect of surface modification of the glass particles using an acid washing technique, designed to increase glass surface hydrophilicity resulting in a homogeneous sample. This study found that acid washing of the glass not only decreased agglomeration and inhomogeneity but also lengthened working times and increased strength of the resultant hydrogel. This lengthened working time, allowed for an increased glass content and, as a result, further increased compressive strength and radiopacity of the resultant hydrogel. Glass particle size analysis revealed that the relative quantity of fine particles was reduced. Surface analysis of the glass particles revealed an increase in hydrophilic silanol groups and increased surface network connectivity. These factors, combined with a decreased surface calcium and an increased surface gallium content, are postulated as the likely reasons for the observed increased strength, working time and hardening time.

Notes

Acknowledgements

This work was supported by Enterprise Ireland Commercialization Fund through the Grant CF/2013/3364.

Compliance with ethical standards

Conflict of interest

There are no conflicts of interest for any authors.

Supplementary material

10853_2017_1466_MOESM1_ESM.png (3 mb)
Supplementary material 1 (PNG 3027 kb)
10853_2017_1466_MOESM2_ESM.eps (362 kb)
Supplementary material 2 (EPS 362 kb)
10853_2017_1466_MOESM3_ESM.eps (139 kb)
Supplementary material 3 (EPS 139 kb)
10853_2017_1466_MOESM4_ESM.eps (1.2 mb)
Supplementary material 4 (EPS 1201 kb)
10853_2017_1466_MOESM5_ESM.png (989 kb)
Supplementary material 5 (PNG 989 kb)

References

  1. 1.
    Brisman JL, Song JK, Newell DW (2006) Cerebral aneurysms. N Engl J Med 355:928–939. doi: 10.1056/NEJMra052760 CrossRefGoogle Scholar
  2. 2.
    Crobeddu E, Lanzino G, Kallmes DF, Cloft HJ (2012) Review of 2 decades of aneurysm-recurrence literature, part 2: managing recurrence after endovascular coiling. Am J Neuroradiol. doi: 10.3174/ajnr.A2958 Google Scholar
  3. 3.
    Kim Nelson P, Levy DI (2001) Balloon-assisted coil embolization of wide-necked aneurysms of the internal carotid artery: medium-term angiographic and clinical follow-up in 22 patients. Am J Neuroradiol 22:19–26Google Scholar
  4. 4.
    Biomaterial Research Group. www.biomaterials.ie
  5. 5.
    Morais DS, Rodrigues MA, Silva TI et al (2013) Development and characterization of novel alginate-based hydrogels as vehicles for bone substitutes. Carbohydr Polym 95:134–142. doi: 10.1016/j.carbpol.2013.02.067 CrossRefGoogle Scholar
  6. 6.
    Brady SA, Fox EK, Lally C, Clarkin OM (2017) Optimisation of a novel glass-alginate hydrogel for the treatment of intracranial aneurysms. Carbohydr Polym. doi: 10.1016/j.carbpol.2017.08.016 Google Scholar
  7. 7.
    Gorodzha S, Douglas TEL, Samal SK et al (2016) High-resolution synchrotron X-ray analysis of bioglass-enriched hydrogels. J Biomed Mater Res A 104:1194–1201. doi: 10.1002/jbm.a.35642 CrossRefGoogle Scholar
  8. 8.
    Barrett EP, Joyner LG, Halenda PP (1951) The determination of pore volume and area distributions in porous substances. I. Computations from nitrogen isotherms. J Am Chem Soc 73:373–380. doi: 10.1021/ja01145a126 CrossRefGoogle Scholar
  9. 9.
    Bismarck A, Boccaccini AR, Egia-Ajuriagojeaskoa E et al (2004) Surface characterization of glass fibers made from silicate waste: zeta-potential and contact angle measurements. J Mater Sci 39:401–412. doi: 10.1023/B:JMSC.0000011493.26161.a6 CrossRefGoogle Scholar
  10. 10.
    Tsomaia N, Brantley SL, Hamilton JP et al (2003) NMR evidence for formation of octahedral and tetrahedral Al and repolymerization of the Si network during dissolution of aluminosilicate glass and crystal. Am Mineral 88:54–67CrossRefGoogle Scholar
  11. 11.
    Simonsen ME, Sønderby C, Li Z, Søgaard EG (2009) XPS and FT-IR investigation of silicate polymers. J Mater Sci 44:2079–2088. doi: 10.1007/s10853-009-3270-9 CrossRefGoogle Scholar
  12. 12.
    Hollinger G, Skheyta-Kabbani R, Gendry M (1994) Oxides on GaAs and InAs surfaces: an x-ray-photoelectron-spectroscopy study of reference compounds and thin oxide layers. Phys Rev B 49:11159–11167. doi: 10.1103/PhysRevB.49.11159 CrossRefGoogle Scholar
  13. 13.
    He H, Cheng C-F, Seal S et al (1995) Solid-state NMR and ESCA studies of the framework aluminosilicate analcime and its gallosilicate analog. J Phys Chem 99:3235–3239. doi: 10.1021/j100010a039 CrossRefGoogle Scholar
  14. 14.
    Sekita M, Fujimori A, Makishima A et al (1985) X-ray photoelectron spectroscopy of a cerium-doped lanthanum aluminosilicate glass. J Non Cryst Solids 76:399–407. doi: 10.1016/0022-3093(85)90014-6 CrossRefGoogle Scholar
  15. 15.
    Crowley CM, Doyle J, Towler MR et al (2007) Influence of acid washing on the surface morphology of ionomer glasses and handling properties of glass ionomer cements. J Mater Sci Mater Med 18:1497–1506. doi: 10.1007/s10856-007-0128-z CrossRefGoogle Scholar
  16. 16.
    Ohyama T, Ko IK, Miura A et al (2004) ProNectin F-grafted-ethylene vinyl alcohol copolymer (EVAL) as a liquid type material for treating cerebral aneurysm: an in vivo and in vitro study. Biomaterials 25:3845–3852. doi: 10.1016/j.biomaterials.2003.10.021 CrossRefGoogle Scholar
  17. 17.
    Prentice LH, Tyas MJ, Burrow MF (2007) Ion leaching of a glass-ionomer glass: an empirical model and effects on setting characteristics and strength. J Mater Sci Mater Med 18:127–131. doi: 10.1007/s10856-006-0670-0 CrossRefGoogle Scholar
  18. 18.
    Takeda S, Yamamoto K, Hayasaka Y, Matsumoto K (1999) Surface OH group governing wettability of commercial glasses. J Non Cryst Solids 249:41–46. doi: 10.1016/S0022-3093(99)00297-5 CrossRefGoogle Scholar
  19. 19.
    Leed EA, Sofo JO, Pantano CG (2005) Electronic structure calculations of physisorption and chemisorption on oxide glass surfaces. Phys Rev B 72:155427. doi: 10.1103/PhysRevB.72.155427 CrossRefGoogle Scholar
  20. 20.
    Leed EA, Pantano CG (2003) Computer modeling of water adsorption on silica and silicate glass fracture surfaces. J Non Cryst Solids 325:48–60. doi: 10.1016/S0022-3093(03)00361-2 CrossRefGoogle Scholar
  21. 21.
    Henkes H, Weber W (2015) The past, present and future of endovascular aneurysm treatment. Clin Neuroradiol 25(Suppl 2):317–324. doi: 10.1007/s00062-015-0403-1 CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.School of Mechanical and Manufacturing EngineeringDublin City UniversityDublin 9Ireland
  2. 2.Materials and Surface Science InstituteUniversity of LimerickLimerickIreland
  3. 3.South Eastern Applied Materials Research CentreWaterford Institute of TechnologyWaterfordIreland
  4. 4.Department of NeuroradiologyBeaumont HospitalDublinIreland
  5. 5.Department of Mechanical and Manufacturing Engineering, School of Engineering, and Trinity Centre For BioengineeringTrinity College DublinDublin 2Ireland

Personalised recommendations