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One-pot multicomponent click synthesis of pyrazole derivatives using cyclodextrin-supported capsaicin nanoparticles as catalyst

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Abstract

Facile and efficient methodology for one-pot multicomponent click synthesis of pyrazole derivatives by using phenyl hydrazine, malononitrile and varying degrees of substituted aldehydes has been described. As a recyclable heterogeneous catalyst, we used CPS-CDMNPs. The nanoparticles were prepared by two-step synthesis using co-precipitation and ultrasonication method for the synthesis of CDMNPs, and further capsaicin was deposited on CDMNPs by wet impregnation method. The catalyst can be recovered in a facile manner from the reaction mixture magnetically by applying magnet outside the flask. Moreover, this protocol features the shortest reaction time, simple procedure, high conversion and no tedious workup procedures.

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Acknowledgements

We are thankful to SAIF, Panjab University, Chandigarh, for FT‐IR, TEM and 1H‐NMR, IIT Ropar for SEM, XRD, 1H‐NMR, 13C‐NMR, CSMCRI Bhavnagar and BIT Bengaluru for BET, CIL IIT Roorkee for VSM. DST-FIST New Delhi, for financial assistance for acquiring the FT-IR at NIT Jalandhar. One of the author (P.A.) is thankful to MHRD and NIT Jalandhar for providing the research fellowship. We would like to thank Mr. Harminder Singh and Miss Jigyasa Badhan for their valuable suggestions in manuscript writing.

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  1. Department of Chemistry, Dr. B R Ambedkar National Institute of Technology, Jalandhar, Punjab, 144011, India

    Priya Arora & Jaspreet Kaur Rajput

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  1. Priya Arora
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  2. Jaspreet Kaur Rajput
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Correspondence to Priya Arora.

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Arora, P., Rajput, J.K. One-pot multicomponent click synthesis of pyrazole derivatives using cyclodextrin-supported capsaicin nanoparticles as catalyst. J Mater Sci 52, 11413–11427 (2017). https://doi.org/10.1007/s10853-017-1304-2

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  • DOI: https://doi.org/10.1007/s10853-017-1304-2

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