Journal of Materials Science

, Volume 52, Issue 15, pp 8998–9005 | Cite as

MAS-NMR support for Hench model in the case of bioactive glass microspheres

  • S. SimonEmail author
  • D. Cacaina
  • M. Vasilescu
  • H. Ylänen
  • M. Hupa
In Honor of Larry Hench


The structural changes occurred in bioactive glass microspheres belonging to the system SiO2–Na2O–P2O5–CaO–K2O–MgO incorporating yttrium were investigated before and after soaking in simulated body fluid (SBF) by X-ray diffraction (XRD) and 31P and 29Si magic angle sample spinning nuclear magnetic resonance (MAS-NMR). The addition of yttrium to the bioactive glass composition induces changes in the behavior of the glass microspheres in SBF. The XRD analysis proves that after the immersion in SBF a crystalline hydroxyapatite-like phase is developed on the microspheres surface. The 29Si and 31P MAS-NMR results show that silicate species with two and three bridging oxygens per SiO4 tetrahedra and PO4 monomeric units are present in the glass structure. After immersion in SBF, new silicate species with four bridging oxygens appear as result of silica-gel layer formed on microspheres surface. The formation of crystalline hydroxyapatite-type layer is reflected by the occurrence of narrow components in 31P MAS-NMR spectra. The NMR results support the Hench model for bioactive glasses behavior in biological environments.


Yttrium Y2O3 Simulated Body Fluid Bioactive Glass Glass Microsphere 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This study was supported by UEFISCDI-Romania, in framework of PN-II PCCA 78/2012 Project.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • S. Simon
    • 1
    Email author
  • D. Cacaina
    • 1
    • 2
  • M. Vasilescu
    • 1
  • H. Ylänen
    • 2
  • M. Hupa
    • 3
  1. 1.Faculty of Physics and Interdisciplinary Research Institute on Bio-Nano-SciencesBabes-Bolyai UniversityCluj-NapocaRomania
  2. 2.Turku Biomaterials CentreUniversity of TurkuTurkuFinland
  3. 3.Process Chemistry CentreÅbo Akademi UniversityTurkuFinland

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