Journal of Materials Science

, Volume 52, Issue 15, pp 8886–8903 | Cite as

Copper-containing glass polyalkenoate cements based on SiO2–ZnO–CaO–SrO–P2O5 glasses: glass characterization, physical and antibacterial properties

  • S. Mokhtari
  • K. D. Skelly
  • E. A. Krull
  • A. Coughlan
  • N. P. Mellott
  • Y. Gong
  • R. Borges
  • A. W. WrenEmail author
In Honor of Larry Hench


A series of copper (Cu)-containing glasses were synthesized and incorporated into a SiO2–ZnO–CaO–SrO–P2O5-based glass system. Additions of 6 and 12 mol% CuO retained the amorphous character, and glasses were processed to possess similar particle sizes and surface areas. Glass characterization using X-ray photoelectron spectroscopy and magic angle spinning nuclear magnetic resonance determined that the addition of 12 mol% CuO increased the fraction of Q4-speciation and the concentration of bridging oxygens. Each glass presented solubility profiles for the release of Si4+ (18–31 mg/L), Ca2+ (13–16 mg/L), Zn2+ (<3 mg/L) and Sr2+(2–10 mg/L); however, no Cu2+ or P5+ were released. Cu-GPCs were formulated, and the working time (T w) and setting times (T s) were found to be dependent on both polyacrylic acid concentration and CuO addition. The mechanical properties, i.e. the compressive strength (18–30 MPa) and the adhesive bond strength (0.79–1.32 MPa), were relative low which is likely due to the glass structure. Antibacterial properties were evaluated in E. coli (4 mm), S. epidermidis (10 mm), S. aureus (UMAS-1) and vancomycin resistant S. aureus (2 mm) and presented antibacterial effects in each microbe tested.


Simulated Body Fluid Bioactive Glass Shear Bond Strength Glass Particle Magic Angle Spin Nuclear Magnetic Resonance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • S. Mokhtari
    • 1
  • K. D. Skelly
    • 1
  • E. A. Krull
    • 2
  • A. Coughlan
    • 2
  • N. P. Mellott
    • 3
  • Y. Gong
    • 1
  • R. Borges
    • 4
  • A. W. Wren
    • 1
    Email author
  1. 1.Kazuo Inamori School of EngineeringAlfred UniversityAlfredUSA
  2. 2.Department of BioengineeringUniversity of ToledoToledoUSA
  3. 3.Department of Chemical Engineering and Materials ScienceMichigan State UniversityEast LansingUSA
  4. 4.Department of Materials Science and EngineeringUniversidade Federal do ABCSao PauloBrazil

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