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Thermal, structural and in vitro dissolution of antimicrobial copper-doped and slow resorbable iron-doped phosphate glasses

  • In Honor of Larry Hench
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Abstract

This paper focuses on investigating and comparing the effects of CuO and Fe2O3 addition on the bioactive response of glass having composition [xCuO or Fe2O3 + (100 − x) (0.2CaO + 0.2SrO + 0.1Na2O + 0.5P2O5)] (in mol%), where x is ranging from 0 up to 5. The addition of CuO was found to increase the hot processing window and the dissolution rate leading to a fast surface layer precipitation. Using IR and Raman spectroscopies, we related this change in the bioactive response of this glass to the progressive depolymerization of the glass network induced by the addition of CuO. On the other hand, the addition of Fe2O3 was found to reduce the hot processing window and the dissolution rate as no depolymerization of the network occurs due to the formation of P–O–Fe bonds at the expense of P–O–P bonds. All the glasses were found to dissolve congruently and in a controlled manner. Finally, the antimicrobial properties of the copper-doped glasses were examined and compared to bioactive glasses which are known to exhibit good antimicrobial properties. The CuO addition leads to higher antimicrobial properties than the commercial bioactive glass S53P4 and total bacterial elimination could be obtained.

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Acknowledgements

The authors would like to acknowledge the support of Academy of Finland for the financial support of Dr. Jonathan Massera through the Academy Research Fellow and Initial Research Cost and for the support of Dr. Laeticia Petit through “COMPETITIVE FUNDING TO STRENGTHEN UNIVERSITY RESEARCH PROFILES funded by Academy of Finland, decision number 310359.” Dr. Maria Pihl and Prof. Martin Andersson acknowledge funding from the Knut and Alice Wallenberg foundation through their Wallenberg Academy Fellows program. Funding was provided by Suomen Akatemia (FI), Academy of Finland (Grant No. 275427, 284492 and 310359), Knut and Alice Wallenburg Foundation.

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Authors and Affiliations

  1. Biomedical Sciences and Engineering, Tampere University of Technology, Korkeakoulunkatu 3, 33720, Tampere, Finland

    A. Mishra, L. Petit & J. Massera

  2. BioMediTech, University of Tampere and Tampere University of Technology, Lääkärinkatu 1, 33520, Tampere, Finland

    A. Mishra & J. Massera

  3. Laboratory of Photonics, Tampere University of Technology, 33720, Tampere, Finland

    L. Petit & T. Salminen

  4. Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Kemivägen 10, 412 96, Gothenburg, Sweden

    M. Pihl & M. Andersson

  5. Equipe Verres et Céramiques, UMR-CNRS 6226, Sciences Chimiques de Rennes, Université de Rennes I, 35042, Rennes Cedex, France

    J. Rocherullé

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  1. A. Mishra
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  2. L. Petit
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Correspondence to J. Massera.

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Mishra, A., Petit, L., Pihl, M. et al. Thermal, structural and in vitro dissolution of antimicrobial copper-doped and slow resorbable iron-doped phosphate glasses. J Mater Sci 52, 8957–8972 (2017). https://doi.org/10.1007/s10853-017-0805-3

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  • DOI: https://doi.org/10.1007/s10853-017-0805-3

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