Journal of Materials Science

, Volume 52, Issue 7, pp 3849–3861 | Cite as

β-Cyclodextrin-grafted TEMPO-oxidized cellulose nanofibers for sustained release of essential oil

  • Seema Saini
  • Deborah Quinot
  • Nathalie Lavoine
  • Mohamed Naceur Belgacem
  • Julien BrasEmail author
Original Paper


The present investigation deals with the development and characterization of a new controlled release packaging system for food. Novel sustained system was developed by direct grafting of beta-cyclodextrin (βCD) on the carboxyl groups of TEMPO-oxidized cellulose nanofibers (TEMPO-CNF) in aqueous solution and without using any spacer. Carvacrol, an aromatic essential oil component, was then entrapped in the ensued CD-grafted TEMPO-CNF. Successful functionalization of TEMPO-CNF was confirmed by conductometric titration, Fourier Transform Infrared Spectroscopy, and gravimetric analyses. The βCD-grafted TEMPO-CNF films exhibited sustained release of carvacrol over 150 h before reaching the equilibrium in water. Antimicrobial activity of carvacrol against Bacillus subtilis was increased (or improved by 47 h) from 3 h when using TEMPO-CNF to around (or against) 50 h when using CD-grafted TEMPO-CNF. These promising results pave the way for the development of new bio-based controlled release packaging materials with efficient antibacterial activity.


Polylactic Acid Carvacrol Conductometric Titration Cellulose Nanofiber Cyanuric Chloride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This research was supported by new generation packaging (NEWGENPAK) Project of the Seven Framework Program of European Research under Grant Agreement No 290098. LGP2 is part of the LabEx Tec 21 (Investissements d’Avenir - Grant Agreement No ANR-11-LABX-0030) and of the Énergies du Futur and PolyNat Carnot Institutes (Investissements d’Avenir - Grant Agreements No ANR-11-CARN-007-01 and ANR-11-CARN-030-01). This research was made possible thanks to the facilities of the TekLiCell platform funded by the Région Rhône-Alpes (ERDF: European regional development fund).


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Seema Saini
    • 1
    • 2
  • Deborah Quinot
    • 2
  • Nathalie Lavoine
    • 3
  • Mohamed Naceur Belgacem
    • 1
    • 2
  • Julien Bras
    • 1
    • 2
    Email author
  1. 1.Univ. Grenoble Alpes, LGP2GrenobleFrance
  2. 2.CNRS, LGP2GrenobleFrance
  3. 3.Department of Biomaterials Science, Graduate School of Agricultural and Life SciencesThe University of TokyoTokyoJapan

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