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Mannose-functionalized core@shell nanoparticles and their interactions with bacteria

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Abstract

This study examined the interaction of mannose-functionalized, metal-doped magnetite@Au core@shell (MA-Mn:Fe3O4@Au) nanoparticles (NPs) with bacteria-prepared magnetically engineered multifunctional nanoplatforms for bacteria sensing and treatment. To date, there have been few reports on metal-doped magnetite@Au core@shell NPs conjugated with a bacteria-targeting moiety. Mn:Fe3O4 NPs as a core were synthesized using a thermal decomposition method. Mn:Fe3O4 NPs, 5.4 ± 0.6 nm in mean diameter, were coated with gold in an organic solvent to produce core@shell (Mn:Fe3O4@Au) NPs, 9.5 ± 1.5 nm in size. The estimated saturation magnetization values of the Mn:Fe3O4 and Mn:Fe3O4@Au NPs were ~36 and ~0.27 emu g−1, respectively. Energy-dispersive X-ray spectroscopy mapping showed that the doped ions and Au ions were well distributed in the same NPs. The Mn:Fe3O4@Au NPs were transferred to water using amphiphilic polymers. The r 2 relaxivity of the aqueous Mn:Fe3O4@Au NPs was 609.6 mM−1 s−1 at 9.4 T. The interaction of the mannose-functionalized Mn:Fe3O4@Au NPs with bacteria was assessed by incubation with Escherichia coli to determine if the binding ability of mannose on the surface of the NPs remained. The resulting NPs may have potential applications in magnetic resonance imaging/optical imaging for the accurate detection of infectious diseases, bacteria sensing based on magnetic/optical signals, and hyper/photothermal therapy against antibiotic-resistant bacteria.

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Acknowledgements

This study was supported by the Korea Multi-purpose Accelerator Complex, the Creative Research Program of the Korea Atomic Energy Research Institute, and the National Research Foundation of Korea (NRF) Grant funded by the Korean Government (MSIP) (No. 2015R1C1A1A01052278).

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Authors and Affiliations

  1. Korea Multi-purpose Accelerator Complex, Korea Atomic Energy Research Institute, Gyeongju, 305-353, Korea

    Jeong Chan Park

  2. School of Chemical Engineering, Yeungnam University, Gyeongsan, 38541, Korea

    Gyeong Tae Lee & Jeong Hyun Seo

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  1. Jeong Chan Park
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  2. Gyeong Tae Lee
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Correspondence to Jeong Hyun Seo.

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Park, J.C., Lee, G.T. & Seo, J.H. Mannose-functionalized core@shell nanoparticles and their interactions with bacteria. J Mater Sci 52, 1534–1545 (2017). https://doi.org/10.1007/s10853-016-0448-9

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