Journal of Materials Science

, Volume 52, Issue 2, pp 721–735 | Cite as

Mechanochemical synthesis and in vitro studies of chitosan-coated InAs/ZnS mixed nanocrystals

  • Zdenka BujňákováEmail author
  • Erika Dutková
  • Anna Zorkovská
  • Matej Baláž
  • Jaroslav KováčJr.
  • Martin Kello
  • Ján Mojžiš
  • Jaroslav Briančin
  • Peter Baláž
Original Paper


In this paper, InAs/ZnS mixed nanocrystals were synthesized by dry high-energy milling approach in the first step. The obtained nanocrystals were characterized from structural point of view by X-ray diffraction analysis and Raman spectroscopy, and from the morphological point of view by scanning electron microscopy. In the next step, the nanocrystals were subjected to wet ultra-fine milling in order to obtain a nanosuspension of chitosan-coated InAs/ZnS nanocrystals with bio-imaging properties. The stability of the nanosuspension was examined by zeta potential and particle size distribution measurements. The prepared nanosuspension was stable with high values of zeta potential. Its optical properties were also studied using UV–Vis and PL spectroscopies. The determined fluorescent properties confirming the potential in bio-imaging applications were verified on cancer cell lines Caco-2, HCT116, HeLa, and MCF7.


Arsenic Chitosan Milling Zeta Potential Particle Size Distribution Measurement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by the Slovak Research and Development Agency under the contract No. APVV-14-0103 and by the Slovak Grant Agency VEGA (project 2/0027/14).


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Zdenka Bujňáková
    • 1
    Email author
  • Erika Dutková
    • 1
  • Anna Zorkovská
    • 1
  • Matej Baláž
    • 1
  • Jaroslav KováčJr.
    • 2
  • Martin Kello
    • 3
  • Ján Mojžiš
    • 3
  • Jaroslav Briančin
    • 1
  • Peter Baláž
    • 1
  1. 1.Institute of GeotechnicsSlovak Academy of SciencesKošiceSlovakia
  2. 2.Institute of Electronics and PhotonicsSlovak University of TechnologyBratislavaSlovakia
  3. 3.Faculty of MedicineP. J. Šafárik UniversityKošiceSlovakia

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