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Journal of Materials Science

, Volume 50, Issue 20, pp 6567–6577 | Cite as

Development and characterization of a self-double-emulsifying drug delivery system containing both epigallocatechin-3-gallate and α-lipoic acid

  • Caibiao Hu
  • Guodong Zhao
  • Qiang XiaEmail author
  • Rui Sun
Original Paper

Abstract

The present study investigated a self-double-emulsifying drug delivery system (SDEDDS) loaded with epigallocatechin-3-gallate (EGCG) and α-lipoic acid to improve EGCG photostability and possess a sustained release behavior. The long chain solid lipids (cetostearyl alcohol) and macadamia oil were utilized as a carrier to co-deliver the two bioactive ingredients. The prepared EA-SDEDDS for topical application was formulated using modified two-step method and characterized by confocal microscopy, in vitro release, and antioxidant effects. EA-SDEDDS was found to be stable under simulated sunlight for 1 month (at room temperature). In vitro cell culture studies, EA-SDEDDS provided protection for 3t3 fibroblasts that underwent H2O2 oxidative stress due to sustained release property. Cellular antioxidant activity assay indicated that EA-SDEDDS showed anti-oxidative capacity with the same efficacy compared to EGCG-α-lipoic acid solution.

Keywords

EGCG Entrapment Efficiency Solid Lipid Halofantrine Simulated Sunlight 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

Appreciation is expressed for the financial support of this research from the International Scientific Cooperation Project of the Ministry of Science and Technology of China (No. 2008DFB50060).

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Caibiao Hu
    • 1
    • 2
  • Guodong Zhao
    • 3
  • Qiang Xia
    • 1
    • 2
    Email author
  • Rui Sun
    • 1
    • 2
  1. 1.School of Biological Science and Medical Engineering, State Key Laboratory of BioelectronicsSoutheast UniversityNanjingChina
  2. 2.Collaborative Innovation Center of Suzhou Nano Science and TechnologySuzhouChina
  3. 3.Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhouChina

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