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Supercritical impregnation of drugs and supercritical fluid deposition of metals into aerogels

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Abstract

The presented review covers the latest research on supercritical impregnation into organic and inorganic aerogels by investigating those factors that influence the impregnation. Supercritical impregnation is a promising method for incorporating drugs within porous carriers including for water insoluble drugs. An additional step (reduction from metallic precursor to metal) is required for the supercritical impregnation of metallic precursors. Hence, this expanded method is preferably termed as supercritical fluid deposition or adsorption. Supercritical impregnation of drugs, as well as metals, are mostly influenced by interactions between the compound and aerogel matrix, supercritical impregnation conditions, and the characteristics of a compound within a supercritical fluid.

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Acknowledgement

The authors wish to acknowledge the Slovenian Research Agency [Grant no.: 1000-11-860046] and University fund Marie Curie ITN project [Grant no.: 316959] for its financial support.

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  1. Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova 17, 2000, Maribor, Slovenia

    Gabrijela Tkalec, Milica Pantić, Zoran Novak & Željko Knez

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  1. Gabrijela Tkalec
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Tkalec, G., Pantić, M., Novak, Z. et al. Supercritical impregnation of drugs and supercritical fluid deposition of metals into aerogels. J Mater Sci 50, 1–12 (2015). https://doi.org/10.1007/s10853-014-8626-0

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