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Beta-cyclodextrin-based molecular-recognizable smart microcapsules for controlled release

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Abstract

Novel molecular-recognizable smart microcapsules for controlled release are successfully fabricated in two steps. Firstly, monodispersed poly(N-isopropylacrylamide-co-acrylic acid) microcapsules are prepared via microfluidic emulsion template synthesis; and then, β-cyclodextrin groups are introduced onto the microcapsules by a condensation reaction. The results of Fourier transform infrared spectrometry confirm that β-cyclodextrin moieties are successfully immobilized onto microcapsules by the condensation reaction between carboxylic groups of acrylic acid components on the microcapsules and amino groups of modified β-cyclodextrin monomers. The resultant poly(N-isopropylacrylamide-co-acrylic acid/aminated β-cyclodextrin) (PNA-ECD) microcapsules show a narrow size distribution. The volume phase transition temperature of prepared PNA-ECD microcapsules exhibits a positive shift in the solution containing model guest molecules 2-naphthalenesulfonic acid (NS). Upon recognizing the guest molecules NS, the PNA-ECD microcapsules show an isothermal and reversible molecular-recognizable swelling behavior. Moreover, the release rate of model drug molecules Fluorescein isothiocyanate-labeled dextran loaded in the microcapsules dramatically increases upon recognizing NS molecules. The results provide valuable guidance for the design and fabrication of monodispersed molecular-recognizable microcapsules for controlled release.

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Acknowledgements

The authors gratefully acknowledge support from the National Natural Science Foundation of China (21136006, 21036002) and the Program for New Century Excellent Talents in University (NCET-11-0352).

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Authors and Affiliations

  1. School of Chemical Engineering, Sichuan University, Chengdu, 610065, People’s Republic of China

    Chao Yang, Rui Xie, Wei-Gang Liang, Xiao-Jie Ju, Wei Wang, Mao-Jie Zhang, Zhuang Liu & Liang-Yin Chu

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  1. Chao Yang
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  2. Rui Xie
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  3. Wei-Gang Liang
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  4. Xiao-Jie Ju
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  8. Liang-Yin Chu
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Correspondence to Rui Xie.

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Yang, C., Xie, R., Liang, WG. et al. Beta-cyclodextrin-based molecular-recognizable smart microcapsules for controlled release. J Mater Sci 49, 6862–6871 (2014). https://doi.org/10.1007/s10853-014-8388-8

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