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Properties and drug release profile of poly(N-isopropylacrylamide) microgels functionalized with maleic anhydride and alginate

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Abstract

This study highlights the advantages of functionalized poly(N-isopropylacrylamide) (PNIPAAm) microgels over pure PNIPAAm microgels in terms of polymer network properties and drug release profiles. PNIPAAm network was modified by addition of maleic anhydride (MA) as a comonomer and by formation of interpenetrating polymer network in the presence of alginate. The functionalized thermosensitive microgels in the size range from 20 to 80 μm and with better performance in comparison with pure PNIPAAm microgels were prepared by inverse suspension polymerization. The impact of MA and alginate on the PNIPAAm microgel structure was evaluated through analysis of microgel size, size distribution, volume phase transition temperature (VPTT), equilibrium swelling ratio as well as morphology of the system. It was shown that the controlled modification of PNIPAAm network could result in microgels of considerably improved swelling capacity with unchanged thermosensitivity and maintained open pore morphology. In addition, drug release behavior of microgels could be markedly altered. Release of procaine hydrochloride from the selected microgels was studied using Franz diffusion cell at temperatures below and above VPTT of the microgels. Temperature-controlled drug release pattern was dependent on the type of functionalization of PNIPAAm network. According to drug loading properties and drug release mechanism, PNIPAAm/MA copolymer microgels demonstrated the optimal performances.

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Acknowledgements

This research was supported under the project ARCUS 2006—Nord-Pas-de-Calais/Bulgarie—Roumanie—Serbie, granted by the French Ministry of Foreign Affairs and the Region Nord-Pas-De-Calais. The research is funded in part by the Ministry of Science of Republic of Serbia (Project Number III46010). The authors acknowledge Dr. Smilja Markovic from the Institute of Technical Sciences of SASA from Belgrade for the laser diffraction analysis.

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Authors and Affiliations

  1. École Nationale Supérieure des Arts et Industries Textiles, GEMTEX, 2 allée Louise et Victor Champier, 59100, Roubaix, France

    Stojanka Petrusic, Maryline Lewandowski, Stephane Giraud & Vladan Koncar

  2. Université Lille Nord de France, 59000, Lille, France

    Stojanka Petrusic, Maryline Lewandowski, Stephane Giraud & Vladan Koncar

  3. Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000, Belgrade, Serbia

    Petar Jovancic, Svetlana Grujic & Branko Bugarski

  4. Institute of General and Physical Chemistry, University of Belgrade, Studentski trg 12-16, 11000, Belgrade, Serbia

    Sanja Ostojic

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  1. Stojanka Petrusic
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  2. Petar Jovancic
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  3. Maryline Lewandowski
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  4. Stephane Giraud
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  8. Vladan Koncar
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Correspondence to Stojanka Petrusic.

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Petrusic, S., Jovancic, P., Lewandowski, M. et al. Properties and drug release profile of poly(N-isopropylacrylamide) microgels functionalized with maleic anhydride and alginate. J Mater Sci 48, 7935–7948 (2013). https://doi.org/10.1007/s10853-013-7604-2

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