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Phosphate salts facilitate the electrospinning of hyaluronic acid fiber mats

  • Polymer Fibers
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Abstract

Electrospinning is a cost effective and facile method to manufacture fiber mats appropriate for biomedical applications. Due to its high molecular weight and charged backbone, hyaluronic acid (HA) fiber mats with consistent fiber morphology have been difficult to electrospin from neutral pH solutions. Here, we present that the electrospinning of HA fibers in aqueous dimethylformamide solutions is facilitated by the addition of three phosphate salts. The salts—glycerol phosphate (GP), sodium phosphate (SP), and tripolyphosphate (TPP)—facilitated electrospinning of the solutions as characterized by conductivity measurements and fiber morphology. From tensile experiments, HA mats electrospun with SP demonstrated improved Young’s modulus (12 MPa) over HA mats spun with either GP or TPP (5 and 3 MPa, respectively). This work demonstrates that a new neutral solvent system can be employed to spin HA fibers, which offers the potential for using the fibers for biomedical applications, such as a bone biomimetic.

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Acknowledgements

The authors would like to thank Janine Kishbaugh and Dr. Larry Quarino from Cedar Crest College for their help with the ATR-FTIR. They acknowledge the use of the Centralized Research Facilities in the College of Engineering at Drexel University and are grateful for funding through NSF-CMMI Grant No. 0804543 and the Ben Franklin Nanotechnology Institute.

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Authors and Affiliations

  1. Department of Materials Science and Engineering, Drexel University, Philadelphia, PA, 19104, USA

    Eric K. Brenner, Laura J. Toth, Janah C. Szewczyk & Caroline L. Schauer

  2. Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, MA, 01003-9303, USA

    Jessica D. Schiffman

Authors
  1. Eric K. Brenner
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  2. Jessica D. Schiffman
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  3. Laura J. Toth
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  4. Janah C. Szewczyk
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  5. Caroline L. Schauer
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Corresponding author

Correspondence to Caroline L. Schauer.

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Brenner, E.K., Schiffman, J.D., Toth, L.J. et al. Phosphate salts facilitate the electrospinning of hyaluronic acid fiber mats. J Mater Sci 48, 7805–7811 (2013). https://doi.org/10.1007/s10853-013-7532-1

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  • DOI: https://doi.org/10.1007/s10853-013-7532-1

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