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A versatile click-grafting approach to surface modification of silk fibroin films

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Abstract

Silk fibroin is a biocompatible, mechanically robust protein polymer that can be made optically transparent, and is widely used and studied as biomaterial for different applications. Its chemical modification is a fascinating way for tuning the properties and widening its application field. Herein, PEG grafting on the surface of regenerated silk fibroin films is obtained by direct linking based on a click reaction between the azido activated silk surface and an alkyne terminated PEG. The so obtained PEGylated films exhibit modified surface properties in comparison with the unmodified films. Through the same click approach, we also show that arrays of ordered fluorescent spots are steadily printed onto the film surface. This expands the versatility of our silk modification to different molecules and polymers, hence allowing for the realization of new functional hybrid materials.

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Acknowledgements

The authors are grateful for the financial support to Regione Lombardia, GreenCosmetic ATP Project and to agreement Regione/CNR, project 4: “Nanoscienze per materiali e applicazioni biomediche”. The authors also thank Guido Scavia (ISMAC-CNR) for AFM analysis.

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Authors and Affiliations

  1. Istituto per lo Studio delle Macromolecole, CNR, Via Bassini 15, 20133, Milan, Italy

    Francesco Galeotti, Anita Andicsova, Fabio Bertini & Chiara Botta

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  1. Francesco Galeotti
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  2. Anita Andicsova
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  3. Fabio Bertini
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  4. Chiara Botta
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Correspondence to Francesco Galeotti.

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Galeotti, F., Andicsova, A., Bertini, F. et al. A versatile click-grafting approach to surface modification of silk fibroin films. J Mater Sci 48, 7004–7010 (2013). https://doi.org/10.1007/s10853-013-7509-0

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  • DOI: https://doi.org/10.1007/s10853-013-7509-0

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